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Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity
ABSTRACT Maraviroc (UK-427,857) is a selective CCR5 antagonist with potent anti-human immunodeficiency virus type 1 (HIV-1) activity and favorable pharmacological properties. Maraviroc is the productExpand
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Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches
Quantitative prediction of human pharmacokinetics is critical in assessing the viability of drug candidates and in determining first‐in‐human dosing. Numerous prediction methodologies, incorporatingExpand
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Double standards and first principles: framing teaching assistant support for pupils with special educational needs
Teaching assistants (TAs) are part of a growing international trend toward paraprofessionals working in public services. There has been controversy over TAs’ deployment and appropriate role whenExpand
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The wider pedagogical role of teaching assistants
Teaching assistants (TAs) comprise a quarter of the school workforce in England and Wales. There has been controversy over TAs' deployment and appropriate role regarding supporting learning and theseExpand
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The effect of support staff on pupil engagement and individual attention
Despite an unprecedented increase in classroom‐based support staff, there are confusing messages about their appropriate deployment and a lack of systematic evidence on their impact. This articleExpand
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Deployment and impact of support staff in schools : the impact of support staff in schools : results from strand 2, wave 2
This study was designed to obtain up to date and reliable data on the deployment and characteristics of support staff and the impact of support staff on pupil outcomes and teacher workloads. TheExpand
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Deployment and impact of support staff in schools : characteristics, working conditions and job satisfaction of support staff in schools (strand 1, waves 1-3 in 2004, 2006 and 2008)
This study was designed to obtain up to date and reliable data on the deployment and characteristics of support staff and the impact of support staff on pupil outcomes and teacher workloads. TheExpand
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The impact of support staff on pupils’ ‘positive approaches to learning’ and their academic progress
In recent years there has been an unprecedented increase in support staff in schools in England and Wales. There were widespread expectations that this will be of benefit to teachers and pupils butExpand
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Challenging and changing how schools use teaching assistants: findings from the Effective Deployment of Teaching Assistants project
Following research on the negative impact of support from teaching assistants (TAs) on pupils' academic progress, there was a clear need for schools to fundamentally reassess the way they use TAs.Expand
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A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT This study provides antimuscarinic agents for overactive bladder (OAB) display variable association with side effects mediated by the central nervous systemExpand
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