R. Webster

Publications74
h-index19
Citations1,217
Highly Influential Citations16
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Neurotransmitters, Drugs and Brain Function
List of Contributors. Preface. SECTION A: BASIC ASPECTS OF NEUROTRANSMITTER FUNCTION. Neurotransmitter Systems and Function: Overview (R.A. Webster). Control of Neuronal Activity (D.A. Brown).… Expand
Neurotransmitters, drugs and disease
TLDR
Applied neuropharmacology: Introduction Parkinsonism dementias schizophrenia epilepsy anxiety, anxiolytic-hypnotics depression painanalgesics, and more. Expand
Levodopa peripheral pharmacokinetics and duration of motor response in Parkinson's disease.
TLDR
It is proposed that the duration of response is primarily determined by levodopa peripheral pharmacokinetics rather than by central pharmacodynamic factors associated with dopamine storage capacity. Expand
Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease.
TLDR
Entacapone (OR-611), a novel COMT inhibitor, was assessed in 12 patients with Parkinson's disease and motor fluctuations in a randomised, double-blind, cross-over, single dose study. Expand
THE EFFECT OF ANTITOXIN ON FIXED AND FREE TOXIN IN EXPERIMENTAL TETANUS.
Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproate
TLDR
The results of this study suggest that the acute depressant effect of valproate is unrelated to its ability to alter the concentration of GABA or aspartate in brain and is most likely due to a postsynaptic action. Expand
Reserpine rigidity and adrenergic neurones.
TLDR
It is concluded that reserpine rigidity might be due to a loss of brain dopamine or to an increase in deaminated metabolites, or both. Expand
Neurotransmitter Systems and Function: Overview
SECOND REPORT ON THE ORGANIZATION OF PHARMACOLOGY IN GREAT BRITAIN
TLDR
In 1971, the supply of pharmacologists exceeded significantly the identifiable demand from pharmacology and toxicology departments, and there was a considerable demand from unknown employers. Expand
Antagonism of caffeine-induced seizures in mice by Ro15-1788.
TLDR
The effect of the benzodiazepine antagonist Ro15-1788 has been tested against caffeine, which induced convulsions in mice and offered protection in lower doses than had been effective previously against other convulsants such as bicuculline and leptazol. Expand
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