Neurotransmitters, Drugs and Brain Function
- R. Webster
- Biology, Psychology
- 27 September 2001
This work focuses on the study and Manipulation of Neurotransmitter Function in Humans, and the role of drugs in drug action and disease states.
Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease.
- M. Merello, A. Lees, R. Webster, M. Bovingdon, A. Gordin
- Medicine, PsychologyJournal of Neurology Neurosurgery & Psychiatry
- 1 February 1994
Entacapone (OR-611), a novel COMT inhibitor, was assessed in 12 patients with Parkinson's disease and motor fluctuations in a randomised, double-blind, cross-over, single dose study.
Neurotransmitters, drugs and disease
Applied neuropharmacology: Introduction Parkinsonism dementias schizophrenia epilepsy anxiety, anxiolytic-hypnotics depression painanalgesics, and more.
Levodopa peripheral pharmacokinetics and duration of motor response in Parkinson's disease.
- P. Kempster, J. Frankel, M. Bovingdon, R. Webster, A. Lees, G. Stern
- Medicine, BiologyJournal of Neurology Neurosurgery & Psychiatry
- 1 June 1989
It is proposed that the duration of response is primarily determined by levodopa peripheral pharmacokinetics rather than by central pharmacodynamic factors associated with dopamine storage capacity.
The effects of oral protein on the absorption of intraduodenal levodopa and motor performance.
- J. Frankel, P. Kempster, M. Bovingdon, R. Webster, A. Lees, G. Stern
- Biology, MedicineJournal of Neurology Neurosurgery & Psychiatry
- 1 September 1989
Findings suggest that competition for levodopa carrier mediated transport by amino acids, is more important at the blood-brain barrier than across the gut mucosa; thereby possibly limiting the efficacy of long-term direct intraduodenal administration of levodOPA.
THE EFFECT OF ANTITOXIN ON FIXED AND FREE TOXIN IN EXPERIMENTAL TETANUS.
Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproate
Reserpine rigidity and adrenergic neurones.
Neurotransmitter Systems and Function: Overview
- R. Webster
- 26 April 2002
SECOND REPORT ON THE ORGANIZATION OF PHARMACOLOGY IN GREAT BRITAIN
In 1971, the supply of pharmacologists exceeded significantly the identifiable demand from pharmacology and toxicology departments, and there was a considerable demand from unknown employers.