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Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, theExpand
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Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation
ABSTRACT Early nutrition affects adult metabolism in humans and other mammals, potentially via persistent alterations in DNA methylation. With viable yellow agouti (Avy ) mice, which harbor aExpand
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Maternal Genistein Alters Coat Color and Protects Avy Mouse Offspring from Obesity by Modifying the Fetal Epigenome
Genistein, the major phytoestrogen in soy, is linked to diminished female reproductive performance and to cancer chemoprevention and decreased adipose deposition. Dietary genistein may also play aExpand
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Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seqExpand
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Epigenetic epidemiology of the developmental origins hypothesis.
Extensive human epidemiologic and animal model data indicate that during critical periods of prenatal and postnatal mammalian development, nutrition and other environmental stimuli influenceExpand
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Ten Putative Contributors to the Obesity Epidemic
The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declinesExpand
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Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus.
IGF2 loss of imprinting (LOI) is fairly prevalent and implicated in the pathogenesis of human cancer and developmental disease; however, the causes of this phenomenon are largely unknown. WeExpand
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Maternal methyl supplements increase offspring DNA methylation at Axin fused
Transient environmental exposures during mammalian development can permanently alter gene expression and metabolism by influencing the establishment of epigenetic gene regulatory mechanisms. TheExpand
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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypicExpand
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Child health, developmental plasticity, and epigenetic programming.
Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditionsExpand
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