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DRR drives brain cancer invasion by regulating cytoskeletal-focal adhesion dynamics
Malignant glioma invasion is a primary cause of brain cancer treatment failure, yet the molecular mechanisms underlying its regulation remain elusive. We developed a novel functional-screening… Expand
Unmet needs in multiple myeloma in Brazil from physicians’ perspective – barriers in quality of life and disease management
Objective: There is an increasing trend of the overall survival rates of multiple myeloma (MM) patients over the years, increasing the necessity to improve their quality of life and attenuate unmet… Expand
Sono, neuropeptídeos e proteases
1 Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP).Rua Napoleão de Barros, no 925. São Paulo SP. Brazil. CEP: 04024-002. 2 Ciências da Saúde, Universidade Federal de São… Expand
Prognostic factors impacting survival in early HER2-positive breast cancer (BC): Results from a 1,142 patients database study.
e12561Background: early systemic therapy has reduced recurrence and mortality from BC, especially among HER2+ subtype. Despite these advances, the difficulty of developing countries in incorporatin...
Pharmacovigilance knowledge in Brazil: perception of participants of oncology patient advocacy group on adverse events reporting
Chronic intermittent hypoxia induces changes on the expression and activity of neprilysin (EC 126.96.36.199) in the brain of rats
Obstructive sleep apnea (OSA) is a frequent sleeping breathing disorder associated with cognitive impairments. Neprilysin (NEP) is responsible for degrading several substrates related to cognition;… Expand
Evaluation of the expression of pigment epitelium derived factor (PEDF) in chronic intermittent hypoxia: validation and choice for best housekeeping genes in the model
Introduction Pigment-Epitelium Derived Factor (PEDF) is a member of the family of the non- inhibitory serpins, distributed in almost all tissues, including CNS, where it is largely expressed.… Expand
Evaluation of the effect of hypoxia on the expression and activity of neprilysin (EC 188.8.131.52), a protease involved on Alzheimer’s disease
Introduction Hypoxia is characterized by reduced oxygen content in blood and is related to several pathologies, including Obstructive Sleep Apnea Syndrome (OSAS). Its consequences are not completely… Expand