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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere. Expand
Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?
  • R. Wang
  • Chemistry, Medicine
  • FASEB journal : official publication of the…
  • 1 November 2002
It is hypothesized that H2S is the third endogenous signaling gasotransmitter, besides nitric oxide and carbon monoxide, and this positioning will open an exciting field‐H2S physiology‐encompassing realization of the interaction of H1N1 and other gasOTransmitters, sulfurating modification of proteins, and the functional role of H2Sin multiple systems. Expand
Complete Transfer of Perceptual Learning across Retinal Locations Enabled by Double Training
A novel double-training paradigm that employed conventional feature training at one location, and additional training with an irrelevant feature/task at a second location enabled a complete transfer of feature learning to the second location, suggesting that perceptual learning involves higher nonretinotopic brain areas that enable location transfer. Expand
Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels
H2S is a major EDHF that causes vascular endothelial and smooth muscle cell hyperpolarization and vasorelaxation by activating the ATP-sensitive, intermediate conductance and small conductance potassium channels through cysteine S-sulfhydration. Expand
Convergent transcriptional specializations in the brains of humans and song-learning birds
The finding that convergent neural circuits for vocal learning are accompanied by convergent molecular changes of multiple genes in species separated by millions of years from a common ancestor indicates that brain circuits for complex traits may have limited ways in which they could have evolved from that ancestor. Expand
The gasotransmitter role of hydrogen sulfide.
  • R. Wang
  • Chemistry, Medicine
  • Antioxidants & redox signaling
  • 1 August 2003
A novel concept of "gasotransmitter" arrived recently. Gasotransmitters are small molecules of endogenous gases with important physiological functions. Their production and metabolism areExpand
Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer.
Investigating the methylation profiles of non-small cell lung cancer in the Chinese population indicated that methylated alteration of multiple genes plays an important role in NSCLC pathogenesis and a panel of candidate epigenetic biomarkers forNSCLC detection in theChinese population was identified. Expand
GARP regulates the bioavailability and activation of TGFβ
GARP disulfide links to latent TGFβ on the cell surface, which serves as a reservoir for TGFβ activation by αVβ6 and to a lesser extent αVβ8. Activation requires the RGD motif of latent TGFβ,Expand
Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.
These results provide a mechanistic insight into how H2S signaling mediates cellular senescence induced by oxidative stress and protects against cellular aging via S-sulfhydration of Keap1 and Nrf2 activation in association with oxidative stress. Expand
The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium Salts
The MTT assay is widely used in cell proliferation and cytotoxicity assays. Most cellular bioreduction of MTT is associated with enzymes of the endoplasmic reticulum and involves the reduced pyridineExpand