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A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission.
- J. Guralnik, E. Simonsick, +5 authors R. Wallace
- Medicine, Psychology
- Journal of gerontology
- 1 March 1994
Evidence is presented that performance measures can validly characterize older persons across a broad spectrum of lower extremity function and that performance and self-report measures may complement each other in providing useful information about functional status. Expand
Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study
Dementia prevalence estimates from this first nationally representative population-based study of dementia in the USA to include subjects from all regions of the country can provide essential information for effective planning for the impending healthcare needs of the large and increasing number of individuals at risk for dementia as the population ages. Expand
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial.
The use of conjugated equine estrogen (CEE) increases the risk of stroke, decreases therisk of hip fracture, and does not affect CHD incidence in postmenopausal women with prior hysterectomy over an average of 6.8 years, indicating no overall benefit. Expand
Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial.
In women with low BMD but without vertebral fractures, 4 years of alendronate safely increased BMD and decreased the risk of first vertebral deformity. Expand
Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery.
- J. Guralnik, L. Ferrucci, +6 authors R. Wallace
- The journals of gerontology. Series A, Biological…
- 1 April 2000
Performance tests of lower extremity function accurately predict disability across diverse populations and Equations derived from models using both the summary score and the gait speed alone allow for the estimation of risk of disability in community-dwelling populations and provide valuable information for estimating sample size for clinical trials of disability prevention. Expand
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
Estrogen plus progestin therapy increased the risk for probable dementia in postmenopausal women aged 65 years or older and did not prevent mild cognitive impairment in these women, supporting the conclusion that the risks of estrogen plus progESTin outweigh the benefits. Expand
Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial.
The results suggest that for many women, discontinuation of alendronate for up to 5 years does not appear to significantly increase fracture risk, however, women at very high risk of clinical vertebral fractures may benefit by continuing beyond 5 years. Expand
Prevalence of Cognitive Impairment without Dementia in the United States
Prevalence rates from what is believed to be the first population-based study of cognitive impairment without dementia to include individuals from all regions of the country are reported, as well as rates of progression from cognitive impairmentWithout dementia to dementia and death. Expand
Sleep complaints among elderly persons: an epidemiologic study of three communities.
In multivariate analyses, sleep complaints were associated with an increasing number of respiratory symptoms, physical disabilities, nonprescription medications, depressive symptoms and poorer self-perceived health. Expand
Calcium plus vitamin D supplementation and the risk of fractures.
- R. Jackson, A. LaCroix, +44 authors D. Barad
- The New England journal of medicine
- 16 February 2006
Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones. Expand