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The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.
The cyclo-octadepsipeptide anthelmintic, emodepside, has pleiotropic effects on the behaviour of the model genetic animal Caenorhabditis elegans: it inhibits locomotion, feeding, egg-laying and slowsExpand
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A human gene encoding morphine modulating peptides related to NPFF and FMRFamide
FMRFamide‐related peptides have been isolated from both invertebrates and vertebrates and exhibit a wide range of biological effects in rats. We show here that in humans 2 FMRFamide‐related peptidesExpand
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Evolution and overview of classical transmitter molecules and their receptors.
All the classical transmitter ligand molecules evolved at least 1000 million years ago. With the possible exception of the Porifera and coelenterates (Cnidaria), they occur in all the remainingExpand
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A review of FMRFamide- and RFamide-like peptides in metazoa
Neuropeptides are a diverse class of signalling molecules that are widely employed as neurotransmitters and neuromodulators in animals, both invertebrate and vertebrate. However, despite theirExpand
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Studies involving avermectin and the 4-aminobutyric acid (GABA) receptor of Ascaris suum muscle†
This study describes the pharmacology of the Ascaris suum muscle GABA receptor using a range of GABA agonists and antagonists. The GABA receptor at this site does not readily fit into GABA-A orExpand
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Characterization of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-alpha2 in the function of the native
Glutamate-gated chloride (GluCl) channels are the site of action of the anthelmintic ivermectin. Previously, the Xenopus laevis oocyte expression system has been used to characterize GluCl channelsExpand
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GABA receptors on the somatic muscle cells of the parasitic nematode, Ascaris suum: stereoselectivity indicates similarity to a GABAA‐type agonist recognition site
1 The γ‐aminobutyric acid (GABA) receptors on the somatic muscle cells of Ascaris, which mediate muscle cell hyperpolarization and relaxation, have been characterized by use of intracellularExpand
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The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum.
Here we report on the action of the novel cyclo-depsipeptide anthelmintic, emodepside, on the body wall muscle of the parasitic nematode, Ascaris suum. Emodepside caused (i) muscle relaxation, (ii)Expand
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Mapping of nerve cells in the suboesophageal ganglia of Helix aspersa.
Abstract o 1. More than 100 different neurones have been investigated in three suboesophageal ganglia (left parietal, visceral and right parietal ganglia) of the snail Helix aspersa. 2. Diagrams andExpand
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Actions of the anthelmintic ivermectin on the pharyngeal muscle of the parasitic nematode, Ascaris suum.
The anthelmintic invermectin has a number of effects on nematodes which result in changes in behaviour, particularly locomotion, including paralysis and an inhibition of feeding. This paper describesExpand
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