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The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.
A human gene encoding morphine modulating peptides related to NPFF and FMRFamide
Evolution and overview of classical transmitter molecules and their receptors
The evidence stresses the similarity between the major phyla rather than their differences, supporting a common origin from primitive helminth stock.
A review of FMRFamide- and RFamide-like peptides in metazoa
The intention is that this focus on the structure and functional aspects of FMRFamide and RFamide-like neuropeptides will inform understanding of conserved principles and distinct properties of signalling across the animal phyla.
Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans.
An introduction to the use of C. elegans as a 'model' parasitic nematode is provided, and approaches that have been of particular value with a view to facilitating wider-use of C.'s elegan as a platform for anthelmintic and nematicide discovery and development are highlighted.
Studies involving avermectin and the 4-aminobutyric acid (GABA) receptor of Ascaris suum muscle†
It was found to inhibit GABA-evoked increase in membrane conductance and membrane hyper polarisation on quiescent muscle cells with an apparent affinity constant in the mid-micromolar range.
Mapping of nerve cells in the suboesophageal ganglia of Helix aspersa.
GABA receptors on the somatic muscle cells of the parasitic nematode, Ascaris suum: stereoselectivity indicates similarity to a GABAA‐type agonist recognition site
- L. Holden-Dye, P. Krogsgaard‐Larsen, L. Nielsen, R. Walker
- BiologyBritish journal of pharmacology
- 1 November 1989
The Ascaris GABA receptor does not recognise agents that are known to block the GABA gated chloride channel in mammalian preparations such as t‐butylbicyclophosphorothionate or the insecticide dieldrin, and the pharmacology of this receptor is discussed in relation to other invertebrate systems and the mammalian subclassification of GABA receptors.
Actions of the anthelmintic ivermectin on the pharyngeal muscle of the parasitic nematode, Ascaris suum
Interruption of pharyngeal processes such as, feeding, regulation of hydrostatic pressure and secretion may provide a new site of anthelmintic action, providing evidence that the pharynx is a site for the action of ivermectin.
Role of beta-adrenergic receptors in inflammatory marker expression in Müller cells.
It is suggested that stimulation of beta-adrenergic receptors with isoproterenol leads to decreased levels of PGE(2), TNF-alpha, and IL-1B protein content, and in both gene expression and protein levels of iNOS in Müller cells cultured in hyperglycemia.