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Evolution and overview of classical transmitter molecules and their receptors.
TLDR
The evidence stresses the similarity between the major phyla rather than their differences, supporting a common origin from primitive helminth stock. Expand
The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.
TLDR
It is suggested that emodepside causes inhibition of feeding via a neuronal SLO-1-dependent pathway which is facilitated by LAT-1 whilst it signals through a latrophilin-independent, SLO -1- dependent pathway, in either neurones or body wall muscle, to inhibit locomotion. Expand
A human gene encoding morphine modulating peptides related to NPFF and FMRFamide
TLDR
It is shown that in humans 2 FMRFamide‐related peptides are encoded by a single gene expressed as a spliced mRNA, suggesting that the encoded protein is subject to cleavage by a tripeptidyl peptidase or by a novel processing mechanism. Expand
A review of FMRFamide- and RFamide-like peptides in metazoa
TLDR
The intention is that this focus on the structure and functional aspects of FMRFamide and RFamide-like neuropeptides will inform understanding of conserved principles and distinct properties of signalling across the animal phyla. Expand
Studies involving avermectin and the 4-aminobutyric acid (GABA) receptor of Ascaris suum muscle†
TLDR
It was found to inhibit GABA-evoked increase in membrane conductance and membrane hyper polarisation on quiescent muscle cells with an apparent affinity constant in the mid-micromolar range. Expand
GABA receptors on the somatic muscle cells of the parasitic nematode, Ascaris suum: stereoselectivity indicates similarity to a GABAA‐type agonist recognition site
TLDR
The Ascaris GABA receptor does not recognise agents that are known to block the GABA gated chloride channel in mammalian preparations such as t‐butylbicyclophosphorothionate or the insecticide dieldrin, and the pharmacology of this receptor is discussed in relation to other invertebrate systems and the mammalian subclassification of GABA receptors. Expand
Characterization of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-alpha2 in the function of the native
TLDR
The GluCl-alpha2 subunit confers ivermectin sensitivity and a high-affinity desensitizing glutamate response on the native pharyngeal Glu cloned from Caenorhabditis elegans. Expand
Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans.
TLDR
An introduction to the use of C. elegans as a 'model' parasitic nematode is provided, and approaches that have been of particular value with a view to facilitating wider-use of C.'s elegan as a platform for anthelmintic and nematicide discovery and development are highlighted. Expand
Role of beta-adrenergic receptors in inflammatory marker expression in Müller cells.
TLDR
It is suggested that stimulation of beta-adrenergic receptors with isoproterenol leads to decreased levels of PGE(2), TNF-alpha, and IL-1B protein content, and in both gene expression and protein levels of iNOS in Müller cells cultured in hyperglycemia. Expand
Mapping of nerve cells in the suboesophageal ganglia of Helix aspersa.
TLDR
The axons from some cells have been traced following intracellular injections of CoCl2 and precipitation of CoS, which supported the electrophysiological method of tracing axons by recording antidromic spikes in the cell body following stimulation of a peripheral nerve. Expand
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