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Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
- D. Botstein, R. White, M. Skolnick, R. W. Davis
- Biology, MedicineAmerican journal of human genetics
- 1 May 1980
A new basis for the construction of a genetic linkage map of the human genome is described, to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests of an individual's DNA.
Initial sequencing and analysis of the human genome.
The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.
A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium.
A genome-wide transcriptional analysis of the mitotic cell cycle.
The genome-wide characterization of mRNA transcript levels during the cell cycle of the budding yeast S. cerevisiae indicates a mechanism for local chromosomal organization in global mRNA regulation and links a range of human genes to cell cycle period-specific biological functions.
Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis.
The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.
Life with 6000 Genes
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration and provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history.
Replication dynamics of the yeast genome.
Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae, finding the two ends of each of the 16 chromosomes are highly correlated in their times of replication.
High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.
- K. Struhl, D. Stinchcomb, S. Scherer, R. W. Davis
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 March 1979
A set of vector DNAs useful for the cloning of DNA fragments in Saccharomyces cerevisiae (yeast) and in Escherichia coli are characterized and general methods for the selection and the analysis of these events are presented.
The TTG gene is required to specify epidermal cell fate and cell patterning in the Arabidopsis root.
- M. Galway, J. Masucci, A. Lloyd, V. Walbot, R. W. Davis, J. Schiefelbein
- Biology, MedicineDevelopmental biology
- 1 December 1994
The results indicate that alterations in TTG activity cause developing epidermal cells to misinterpret their position and differentiate into inappropriate cell types, suggesting that, in wild-type roots, TTG provides, or responds to, positional signals to cause differentiating epidersmal cells that lie over cortical cells to adopt a hairless cell fate.
Separation of large DNA molecules by contour-clamped homogeneous electric fields.
Electric fields can be manipulated by a method in which multiple electrodes are arranged along a closed contour and clamped to predetermined electric potentials and the pattern of separation is independent of position in the gel, which is an advantage over previous methods.