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Recommended diagnostic criteria for paraneoplastic neurological syndromes
TLDR
An international panel of neurologists interested in PNS recommended new criteria for those in whom no clinical consensus was reached in the past and defined “classical” syndrome and onconeural antibody as “well characterised”.
Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.
TLDR
The combination of symptoms, MRI findings and paraneoplastic antibodies established the diagnosis of PLE in 78% of the patients, and treatment of the tumour appeared to have more effect on the neurological outcome than the use of immune modulation.
Screening for tumours in paraneoplastic syndromes: report of an EFNS Task Force
TLDR
Screening for tumours in Paraneoplastic neurological syndromes almost invariably predate detection of the malignancy and should be performed as soon as possible.
Management of paraneoplastic neurological syndromes: report of an EFNS Task Force
TLDR
Immune therapy usually has no or modest effect on the CNS syndromes, whereas such therapy is beneficial for PNS affecting the neuromuscular junction, and Symptomatic therapy should be offered to all patients with PNS.
Early palliative care for patients with metastatic cancer
TLDR
Although this concept is already becoming increasingly implemented in tertiary (comprehensive cancer-) care settings, the potential of this approach should be explored for other clinical settings such as office-based oncology.
Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”
This first German evidence-based guideline for cutaneous melanoma was developed under the auspices of the German Dermatological Society (DDG) and the Dermatologic Cooperative Oncology Group (DeCOG)
Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy
TLDR
Around half of patients with TLE-HS presenting to this tertiary center within 6 years of epilepsy onset have evidence consistent with an autoimmune process, which might lead directly to this syndrome.
Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases
TLDR
Refining and expanding the range of anti-Ma/anti-Ta associated neurological presentations and tumours clearly demonstrated that the distinction between anti- Ma and anti- Ta associated PNS is of high clinical relevance.
Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders.
TLDR
It is demonstrated that some patients with paraneoplastic neurological disorders develop antibodies against Mal, a new member of an expanding family of 'brain/testis' proteins.
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