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VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
TLDR
It is indicated that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice.
Hypodontia and Tooth Formation in Groups of Children with Cleft, Siblings without Cleft, and Nonrelated Controls
TLDR
The cleft subjects with siblings showed a significantly higher occurrence of hypodontia and asymmetric dental development than the noncleft control group, which may suggest a genetic component for the occurrence of hypnotism and asymmetrical dental development.
Toll‐like receptor‐1, ‐2, and ‐6 polymorphisms influence disease extension in inflammatory bowel diseases
TLDR
TLR2 and its cofactors TLR1 and TLR6 are involved in the initial immune response to bacteria by recognizing peptidoglycan and an association between nonsynonymous variants in theTLR1, ‐2, and ‐6 genes and extensive colonic disease in UC and CD was found.
The BDNF Val66Met × 5‐HTTLPR × child adversity interaction and depressive symptoms: An attempt at replication
TLDR
Higher order interaction effects involving BDNF Val66Met, 5‐HTTLPR and childhood adversity may contribute to the etiology of depressive illness.
The Belgian PCB and dioxin incident of January-June 1999: exposure data and potential impact on health.
TLDR
Because food items differed widely (more than 50-fold) in the ratio of PCBs to dioxins, other significant sources of contamination and a high background contamination are likely to contribute substantially to the exposure of the Belgian population.
Microbiota conservation and BMI signatures in adult monozygotic twins
TLDR
The difference in microbial networks suggests a shift in fermentation patterns at the end of the colon, which could affect human energy homeostasis.
Familial aggregation in Crohn's disease: increased age-adjusted risk and concordance in clinical characteristics.
TLDR
This study confirms familial aggregation and a high degree of disease concordance in Crohn's disease and confirms the age at diagnosis and initial disease location was especially strong within generations.
VEGF: A modifier of the del22q11 (DiGeorge) syndrome?
TLDR
It is reported that absence of the Vegf164 isoform caused birth defects in mice, reminiscent of those found in del22q11 patients, and genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defect in the del 22q11 syndrome.
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