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High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats
The subthalamic nucleus (STN) plays an important role in motor and non-motor behavior in Parkinson's disease, but its involvement in gait functions is largely unknown. In this study, we investigatedExpand
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Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease
Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis thatExpand
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Memory deficits in the transgenic rat model of Huntington's disease
Memory deficits are common in patients with Huntington's disease (HD) and have a substantial impact on the quality of life of patients and their relatives. A good model resembling the human memoryExpand
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High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour
Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) and one of its target structures, the ventromedial hypothalamus (VMH), produces a typical behaviour in rats consisting ofExpand
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Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats
5-HT(1A) modulation within the midbrain periaqueductal gray (PAG) is closely associated with anxiety- or panic-like behavior. Several findings have demonstrated that the properties of buspirone (aExpand
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Motor and non-motor behaviour in experimental Huntington's disease
In this study, we investigated motor and non-motor behaviour in the transgenic rat model of Huntington's disease (tgHD). In particular, we were interested in the development and changes of motor andExpand
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Changes in brainstem serotonergic and dopaminergic cell populations in experimental and clinical Huntington’s disease
The predominant motor symptom in Huntington's disease (HD) is chorea. The patho-anatomical basis for the chorea is not well known, but a link with the dopaminergic system has been suggested byExpand
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Cognitive and limbic effects of deep brain stimulation in preclinical studies.
The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation hasExpand
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  • Open Access
Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray
Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) has frequently been shown to induce escape and freezing/decreased locomotion responses which mimic panic- and fear-likeExpand
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Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats
Huntington's disease (HD) is characterized by neuronal loss in the striatum, ultimately leading to an 'imbalance' in the electrical activity of the basal ganglia-thalamocortical circuits. To restoreExpand
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