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Synthesis of 9α-hydroxysteroids by a Rhodococcus sp.
Abstract 9α-Hydroxylation of Δ5-3β-hydroxysteroids (of androstane, pregnane, 24-nor- and 21,24-bisnorcholane groups) was carried out by a Rhodococcus sp. , isolated from a petroleum-containing soilExpand
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Long-acting contraceptive agents: Cyclopropyl and cyclobutyl esters of norethisterone
Several esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) with carboxylic acids containing a cyclopropyl or cyclobutyl ring have been synthesized and the stereochemistries ofExpand
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Synthesis of galanthamine: intramolecular para-ortho-coupling of diaryl ethers by anodic oxidation
Abstract Intramolecular para-ortho-coupling of the amide 4 to 7 was achieved by anodic oxidation in acetonitrile solution (containing 2% of methanol) in eighty % yield.
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Microbial transformation of 3-desoxy-dihydromorphinanes
Summary3-Desoxymorphinanes should be transformed by microbial hydroxylation of the aromatic ring to morphinanes. Instead of this reaction the investigated N-derivatives (H, CH3, COCH2OH andExpand
Microbial transformations of galanthamin-precursors
SummaryGalanthamin is a medical important alkaloid. Its chemical synthesis gives a racemic product in low yields. Starting with a belladinderivative an enzymatic ring closure should lead exclusivelyExpand
A New Synthesis of Roxatidine Acetate
Abstract A new four-step synthesis of N-{3-[3-(l-piperidinylmethyl)-phenoxy]propyl}acetoxyacetamide hydrochloride has been performed. The key aralkyl ether was synthesized in high yield underExpand
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Synthesis of polysubstituted 2,4-dimethylquinolines as potential antimalarial drugs
A synthetic way for obtaining 6-amino-2,4-dimethylquinoline derivatives from 2,5-dichloraniline by successive ring closure, nitration, aromatic substitution at so activated quinoline ring, followedExpand
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Microbiological dehydrogenation of polyfunctional Δ5-3β-acetoxy steroids by Corynebacterium mediolanum strain B-964
SummaryA high-yield microbiological transformation of polyfunctional Δ5-3β-acetoxy steroids, containing an additional ring E, by Corynebacterium mediolanum strain B-964 was carried out, resulting inExpand
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