• Publications
  • Influence
Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
Females have reduced brain edema compared to males after experimental brain trauma, although contradictory reports exist as to whether this is due to either estrogen or progesterone. In the presentExpand
  • 120
  • 10
Soluble amyloid precursor protein α reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats
Amyloid precursor protein (APP) has previously been shown to increase following traumatic brain injury (TBI). Whereas a number of investigators assume that increased APP may lead to the production ofExpand
  • 165
  • 10
The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains
The amyloid precursor protein (APP) is known to increase following traumatic brain injury (TBI). This increase in levels of APP may be deleterious to outcome due to the production of neurotoxic Aβ.Expand
  • 72
  • 8
Human Adult Dental Pulp Stem Cells Enhance Poststroke Functional Recovery Through Non‐Neural Replacement Mechanisms
Human adult dental pulp stem cells (DPSCs), derived from third molar teeth, are multipotent and have the capacity to differentiate into neurons under inductive conditions both in vitro and followingExpand
  • 108
  • 6
Magnesium Attenuates Post-Traumatic Depression/Anxiety Following Diffuse Traumatic Brain Injury in Rats
Objective: Magnesium (Mg) declines after traumatic brain injury (TBI), a decline believed associated with ensuing neuronal cell death and subsequent functional impairment. While Mg’s effects on motorExpand
  • 71
  • 5
Differential Effects of 670 and 830 nm Red near Infrared Irradiation Therapy: A Comparative Study of Optic Nerve Injury, Retinal Degeneration, Traumatic Brain and Spinal Cord Injury
Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to theExpand
  • 32
  • 4
  • PDF
A Substance P Antagonist Improves Outcome in Female Sprague Dawley Rats Following Diffuse Traumatic Brain Injury
Over the past decade it has become increasingly clear from work in experimental models that the secondary injury cascade following traumatic brain injury (TBI) may differ between males and femalesExpand
  • 22
  • 4
The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96‐110
We have previously shown that following traumatic brain injury (TBI) the presence of the amyloid precursor protein (APP) may be neuroprotective. APP knockout mice have increased neuronal death andExpand
  • 41
  • 3
Substance P antagonists as a novel intervention for brain edema and raised intracranial pressure.
Increased intracranial pressure (ICP) following acute brain injury requires the accumulation of additional water in the intracranial vault. One source of such water is the vasculature, although theExpand
  • 34
  • 3
  • PDF
Interaction between anesthesia, gender, and functional outcome task following diffuse traumatic brain injury in rats.
A number of experimental and clinical studies have demonstrated that functional outcome following traumatic brain injury differs between males and females. Some studies report that females have aExpand
  • 70
  • 2