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Attenuated peptide YY release in obese subjects is associated with reduced satiety.
The responses of the gut hormone peptide YY (PYY) to food were investigated in 20 normal-weight and 20 obese humans in response to six test meals of varying calorie content. Human volunteers had aExpand
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Remission of Type 2 Diabetes After Gastric Bypass and Banding: Mechanisms and 2 Year Outcomes
Objective: To investigate the rate of type 2 diabetes remission after gastric bypass and banding and establish the mechanism leading to remission of type 2 diabetes after bariatric surgery. SummaryExpand
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Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding
Objectives Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects onExpand
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The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control.
Gastric bypass leads to the remission of type 2 diabetes independently of weight loss. Our hypothesis is that changes in bile flow due to the altered anatomy may partly explain the metabolic outcomesExpand
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Endoscopic Duodenal–Jejunal Bypass Liner Rapidly Improves Type 2 Diabetes
BackgroundBariatric procedures excluding the proximal small intestine improve glycemic control in type 2 diabetes within days. To gain insight into the mediators involved, we investigated factorsExpand
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Changes in gut hormones after bariatric surgery
Bariatric surgery is one of the most effective treatments for achieving long‐term weight loss in morbidly obese patients. Bariatric surgery causes weight loss through substantial decline of hungerExpand
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Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects.
Circulating levels of the gastric hormone ghrelin rise before and decrease after a meal. In normal-weight subjects, postprandial suppression of ghrelin is proportional to calories consumed. ObeseExpand
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Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes
Since the publication of the above article it has been noted that the author S O'Brien should have been listed as CS O'Brien. The authors should therefore appear as follows: R Dutia, M Embrey, CSExpand
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Mechanisms of Disease: the role of gastrointestinal hormones in appetite and obesity
The obesity epidemic is fast becoming one of the leading causes of mortality and morbidity worldwide. Over the past 30 years, gastrointestinal hormones have been increasingly understood to have anExpand
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The satiety hormone peptide YY as a regulator of appetite
Obesity is a major cause of premature death in the UK, and may contribute to as many as 30 000 deaths a year in the UK. Although effective treatment for obesity is still awaited, many developmentsExpand
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