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Structural and functional aspects of the respiratory chain of synaptic and nonsynaptic mitochondria derived from selected brain regions
Studies on brain mitochondria are complicated by the regional, cellular, and subcellular heterogeneity of the central nervous system. This study was performed using synaptic and nonsynapticExpand
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Neuroprotection for ischaemic stroke: current status and challenges.
Stroke is the third cause of death worldwide and the main cause of chronic, severe adult disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all strokes. TheExpand
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Affective disorders, antidepressant drugs and brain metabolism
There is increasing evidence that affective disorders are associated with dysfunction of neurotransmitter postsynaptic transduction pathways and that chronic treatment with clinically active drugsExpand
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Post‐stroke depression: Mechanisms and pharmacological treatment
ABSTRACT Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively affects survivals' functional outcome, response to rehabilitation and quality of life.Expand
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The mitochondrial electron transfer alteration as a factor involved in the brain aging
The tissutal concentrations of reduced glutathione (GSH) and the contents of some key components in the electron transfer chain (namely ubiquinone, cytochromes b, c1, c, and aa3) of the intraterminalExpand
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Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat
We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum,Expand
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The Neurobiology of Depression: an Integrated Overview from Biological Theories to Clinical Evidence
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led to the formulation of several aethiopathological hypotheses. This heterogeneity may account for the followingExpand
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Influence of aging and drug treatment on the cerebral glutathione system
Age-related changes of the components of the glutathione system (reduced and oxidized glutathione) were evaluated in forebrains from male Wistar rats aged 5, 10, 15, 20, 25, 30 and 35 months. TheExpand
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Influence of oxidative stress on the age-linked alterations of the cerebral glutathione system.
The glutathione system (reduced and oxidized glutathione; redox index) was studied in the forebrain of male Wistar rats of 5, 15, and 25 months of age following the administration for 2 months inExpand
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Pharmacological therapy of acute ischaemic stroke: Achievements and problems.
Acute ischaemic stroke (AIS) is a leading cause of death and disability worldwide. Its incidence and prevalence increase considerably with age and numbers will grow with an ageing population.Expand
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