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How to Define a Positive Circumferential Resection Margin in T3 Adenocarcinoma of the Esophagus
A positive circumferential resection margin (CRM+) is associated with poor survival after esophagectomy for cancer. The Royal College of Pathologists (RCP) defines a CRM+ when tumor is found <1 mm ofExpand
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Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer, a randomized controlled trial (ROBOT trial)
BackgroundFor esophageal cancer patients, radical esophagolymphadenectomy is the cornerstone of multimodality treatment with curative intent. Transthoracic esophagectomy is the preferred surgicalExpand
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Minimally invasive surgery compared to open procedures in esophagectomy for cancer: a systematic review of the literature.
The impact of minimally invasive esophagectomy (MIE) on short term perioperative outcomes as opposed to open transhiatal esophagectomy (THE) and transthoracic esophagectomy (TTE) is still underExpand
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Over-expression of phosphorylated mammalian target of rapamycin is associated with poor survival in oesophageal adenocarcinoma: a tissue microarray study
Background Protein kinase mammalian target of rapamycin (mTOR) is an important downstream effector of the phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway. In several tumour types,Expand
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Oncologic Long-Term Results of Robot-Assisted Minimally Invasive Thoraco-Laparoscopic Esophagectomy with Two-Field Lymphadenectomy for Esophageal Cancer
BackgroundOpen transthoracic esophagectomy is the worldwide gold standard in the treatment of resectable esophageal cancer. Robot-assisted minimally invasive thoraco-laparoscopic esophagectomyExpand
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Cyclooxygenase Isoenzyme-2 and Vascular Endothelial Growth Factor are Associated with Poor Prognosis in Esophageal Adenocarcinoma
BackgroundCyclooxygenase isoenzyme-2 (COX-2) and vascular endothelial growth factor (VEGF) contribute to angiogenesis and are overexpressed in various malignancies. The aim of the study was toExpand
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End-to-End Cervical Esophagogastric Anastomoses Are Associated with a Higher Number of Strictures Compared with End-to-Side Anastomoses
BackgroundLeakage and benign strictures occur frequently after esophagectomy. The objective of this study was to analyze the outcome of hand-sewn end-to-end versus end-to-side cervicalExpand
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A New Clinical Scoring System to Define Pneumonia following Esophagectomy for Cancer
Background: Pneumonia is a frequently observed complication following esophagectomy. The lack of a uniform definition of pneumonia leads to large variations of pneumonia rates in literature. ThisExpand
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Fibrin-thrombin coated sealant increases strength of esophagogastric anastomoses in a rat model.
BACKGROUND Anastomotic leakage is a feared complication after esophagectomy. The purpose of this study was to investigate whether the use of a fibrin-thrombin coated collagen patch (TachoSil;Expand
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Risk of Thromboembolic Events after Perioperative Chemotherapy Versus Surgery Alone for Esophageal Adenocarcinoma
BackgroundMajor oncologic surgery is associated with a high incidence of thromboembolic events (TEE). Addition of perioperative chemotherapy in esophageal cancer surgery may increase the risk ofExpand
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