R. Velmurugan

Publications25
h-index8
Citations259
Highly Influential Citations15
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Publisher Correction: Super-resolution fight club: assessment of 2D and 3D single-molecule localization microscopy software
TLDR
In the version of this paper originally published, Figure 4a contained errors that were introduced during typesetting. Expand
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Super-resolution fight club: Assessment of 2D & 3D single-molecule localization microscopy software
TLDR
This study reports results from the second community-wide single-molecule localization microscopy software challenge, which tested over 30 software packages on realistic simulated data for multiple popular 3D image acquisition modes, as well as 2D localization microscopeopy. Expand
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RAB-5 Controls the Cortical Organization and Dynamics of PAR Proteins to Maintain C. elegans Early Embryonic Polarity
In all organisms, cell polarity is fundamental for most aspects of cell physiology. In many species and cell types, it is controlled by the evolutionarily conserved PAR-3, PAR-6 and aPKC proteins,… Expand
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The Encephalitogenic, Human Myelin Oligodendrocyte Glycoprotein–Induced Antibody Repertoire Is Directed toward Multiple Epitopes in C57BL/6-Immunized Mice
Although Abs specific for myelin oligodendrocyte glycoprotein (MOG) have been detected in patients with multiple sclerosis (MS), their contribution to pathogenesis remains poorly understood.… Expand
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FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions.
The neonatal Fc receptor, FcRn, is related to MHC class I with respect to its structure and association with β2microglobulin (β2m). However, by contrast with MHC class I molecules, FcRn does not bind… Expand
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Macrophage-Mediated Trogocytosis Leads to Death of Antibody-Opsonized Tumor Cells
Understanding the complex behavior of effector cells such as monocytes or macrophages in regulating cancerous growth is of central importance for cancer immunotherapy. Earlier studies using… Expand
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A two-stage method for automated detection of ring-like endosomes in fluorescent microscopy images
TLDR
This paper proposes a two-stage method for automated detection of ring-like endosomes in fluorescent microscopy images. Expand
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Myelin oligodendrocyte glycoprotein-specific antibodies from multiple sclerosis patients exacerbate disease in a humanized mouse model.
Myelin oligodendrocyte glycoprotein (MOG) is exposed on the outer surface of the myelin sheath, and as such, represents a possible target antigen for antibodies in multiple sclerosis (MS) and other… Expand
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Phagocytosis of antibody‐opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages
Despite the rapidly expanding use of antibody‐based therapeutics to treat cancer, knowledge of the cellular processes following phagocytosis of antibody‐opsonized tumor cells is limited. Here we… Expand
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Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis
ABSTRACT The maintenance of the homeostasis of immunoglobulin G (IgG) represents a fundamental aspect of humoral immunity that has direct relevance to the successful delivery of antibody-based… Expand
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