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Purification and characterization of an alkaline keratinase from Streptomyces sp.
ONECUT2 is a driver of neuroendocrine prostate cancer
ONECUT2 is reported to drive NEPC tumorigenesis via regulation of hypoxia signaling and tumorHypoxia directed therapy to be effective in NEPC is found, highlighting the potential of Hypoxia-directed therapy for NEPC patients.
Purification and characterization of a solvent and detergent-stable novel protease from Bacillus cereus.
Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.
This study identifies the flavoprotein P450 (cytochrome) oxidoreductase (POR) as a potential predictive biomarker of HAP sensitivity that should be explored during the clinical development of SN30000, TH-302, and other hypoxia-directed agents.
Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin.
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration
Binformatic analyses revealed that CHCHD2 is consistently coamplified with EGFR in non–small cell lung carcinoma (NSCLC) and EGFR protein expression levels were positively correlated and upregulated relative to normal lung in NSCLC tumor-derived xenografts.
Purification and characterization of two novel extra cellular proteases from Serratia rubidaea
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
It is reported that genetic or pharmacological inhibition of GLUT1 with BAY-876 impairs the growth of a subset of TNBC cells displaying high glycolytic and lower oxidative phosphorylation (OXPHOS) rates.
Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.
- L. J. Edgar, R. Vellanki, T. McKee, D. Hedley, B. Wouters, M. Nitz
- Biology, ChemistryAngewandte Chemie
- 6 October 2016
Changes in the oxygenation state of microenvironments within solid tumors are associated with the development of aggressive cancer phenotypes. Factors that influence cellular hypoxia have been…