• Publications
  • Influence
Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly inExpand
  • 915
  • 30
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resultedExpand
  • 1,387
  • 29
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus–cell fusion
Human immunodeficiency virus type 1 (HIV-1) continues to spread, principally by heterosexual sex, but no vaccine is available. Hence, alternative prevention methods are needed to supplementExpand
  • 307
  • 16
Deregulation of cell growth by the K1 gene of Karposi's sarcoma-associated herpesvirus
At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi's sarcoma-associated herpesvirus (KSHV) contains a distinct open readingExpand
  • 292
  • 15
Dynamics of CCR5 Expression by CD4+ T Cells in Lymphoid Tissues during Simian Immunodeficiency Virus Infection
ABSTRACT Early viral replication and profound CD4+ T-cell depletion occur preferentially in intestinal tissues of macaques infected with simian immunodeficiency virus (SIV). Here we show that a muchExpand
  • 243
  • 14
Progesterone implants enhance SIV vaginal transmission and early virus load
Simian immunodeficiency virus (SIV) can cross the intact vaginal epithelium to establish a systemic infection in macaques (mac). Using this SIVmac model, we found that subcutaneous progesteroneExpand
  • 420
  • 13
Acute Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian Immunodeficiency Virus Virulence1
The predictive value of acute gut-associated lymphoid tissue (GALT) CD4+ T cell depletion in lentiviral infections was assessed by comparing three animal models illustrative of the outcomes of SIVExpand
  • 262
  • 13
A macaque model of HIV-1 infection
The lack of a primate model that utilizes HIV-1 as the challenge virus is an impediment to AIDS research; existing models generally employ simian viruses that are divergent from HIV-1, reducing theirExpand
  • 146
  • 13
Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120
A topical microbicide reduces the probability of virus transmission when applied to the vagina or rectum of a person at risk of sexually acquiring HIV-1 infection. An effective microbicide couldExpand
  • 478
  • 12
SIVmac pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans
ObjectiveTo develop a SIV–rhesus macaque (Rh) model of AIDS that more closely approximates HIV pathogenesis in humans. DesignThe pathogenesis of SIV was compared in two different types of Rh, theExpand
  • 191
  • 11