Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond
- M. Pencina, R. B. D' Agostino, R. B. D' Agostino, R. Vasan
- MathematicsStatistics in Medicine
- 30 January 2008
Two new measures, one based on integrated sensitivity and specificity and the other on reclassification tables, are introduced that offer incremental information over the AUC and are proposed to be considered in addition to the A UC when assessing the performance of newer biomarkers.
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
A sex-specific multivariable risk factor algorithm can be conveniently used to assess general CVD risk and risk of individual CVD events (coronary, cerebrovascular, and peripheral arterial disease and heart failure) and can be used to quantify risk and to guide preventive care.
Metabolite profiles and the risk of developing diabetes
Findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.
Vitamin D Deficiency and Risk of Cardiovascular Disease
Vitamin D deficiency is associated with incident cardiovascular disease and further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Obesity and the risk of heart failure.
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study
These findings are consistent with the hypothesized role of visceral fat as a unique, pathogenic fat depot and Measurement of VAT may provide a more complete understanding of metabolic risk associated with variation in fat distribution.
Genome-wide association study of blood pressure and hypertension
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7.
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Long-term trends in the incidence of and survival with heart failure.
Over the past 50 years, the incidence ofheart failure has declined among women but not among men, whereas survival after the onset of heart failure has improved in both sexes.
Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease.
- J. Meigs, P. Wilson, R. D'Agostino
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 August 2006
Assessment of risk for diabetes or cardiovascular disease stratified by body mass index and the presence or absence of metabolic syndrome (MetS) or insulin resistance (IR) found people with normal weight and MetS or IR or with obesity but no MetS and IR were not uncommon in this sample.