R. Van Tassell

Publications40
h-index22
Citations1,338
Highly Influential Citations41
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The enterotoxin of Bacteroides fragilis is a metalloprotease.
During the past decade, strains of Bacteroides fragilis that produce an enterotoxin have been implicated in diarrheal disease in animals and humans. The extracellular enterotoxin has been purified… Expand
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Purification and characterization of an enterotoxin from Bacteroides fragilis.
An enterotoxin produced by Bacteroides fragilis was purified to homogeneity and characterized as to its biological activity and basic molecular properties. Toxin preparations were prepared by growing… Expand
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Bacteriophages of Bacteroides.
Sixty-eight bacteriophages specific for nine species (DNA homology groups) of Bacteroides were isolated from sewage. Four distinct morphological types were isolated, three of which had not previously… Expand
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Characterization of enterotoxigenic Bacteroides fragilis by a toxin-specific enzyme-linked immunosorbent assay.
Within the past decade, certain strains of Bacteroides fragilis have been associated with diarrhea in humans and cytotoxic activity on certain colon carcinoma cell lines. An enzyme-linked… Expand
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Stimulation of mutagen production in human feces by bile and bile acids.
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Case-control study of colorectal cancer and fecapentaene excretion.
The fecapentaenes are potent mutagens found in high concentrations in the stools of some individuals. These compounds are produced in vivo by common species of the colonic microflora, from precursors… Expand
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Case-control study of colorectal cancer and fecal mutagenicity.
Fecal mutagenicity was measured in 68 patients with colorectal cancer and in 114 controls, using Salmonella tester strains TA98 and TA100 with and without S9 activation. Samples were also tested for… Expand
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Isolation of auxotrophs of Bacteroides fragilis.
Techniques employing ethane methanesulfonate and modified penicillin enrichment were developed whereby auxotrophs of Bacteroides fragilis could be readily isolated. Several auxotrophic phenotypes are… Expand
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Purification and characterization of alpha-toxin produced by Clostridium novyi type A.
Our study describes the production, purification, and properties of alpha-toxin from Clostridium novyi type A 19402. The bacterium produced maximal amounts of alpha-toxin when grown at 37 degrees C… Expand
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The normal intestinal microflora: ecology, variability and stability.
The composition and functions of the intestinal floras from humans and other animals is compared and contrasted. Intrinsic and extrinsic factors, such as anatomy, age, and diet, help define the… Expand
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