R. Valenta

Publications507
h-index83
Citations23,649
Highly Influential Citations487
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Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells
The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small… Expand
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Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal
Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis. However, increasing… Expand
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Allergen immunotherapy: therapeutic vaccines for allergic diseases
ABBREVIATIONS AAAAI: American Academy of Allergy, Asthma and Immunology AU: Allergy Unit BAU: Bioequivalent Allergy Unit BU: Biologic Unit CBER: Center for Biologic Evaluation and Research EAACI:… Expand
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Release of allergens as respirable aerosols: A link between grass pollen and asthma.
BACKGROUND Asthma incidence has long been linked to pollen, even though pollen grains are too large to penetrate into the airways where asthmatic responses originate. Pollen allergens found in small,… Expand
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Analysis of the sensitization profile towards allergens in central Africa
Background Almost no information is available regarding the prevalence of IgE‐mediated allergies and the disease‐eliciting allergens in tropical Africa.
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The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene.
Pollen of the white birch (Betula verrucosa) is one of the main causes of Type I allergic reactions (allergic rhinoconjunctivitis, allergic bronchial asthma) in Middle and Northern Europe, North… Expand
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Microinjected profilin affects cytoplasmic streaming in plant cells by rapidly depolymerizing actin microfilaments
BACKGROUND Cytoplasmic streaming is a conspicuous feature of plant cell behaviour, in which organelles and vesicles shuttle along cytoplasmic strands that contain actin filaments. The mechanisms that… Expand
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FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro.
BACKGROUND Atopic dermatitis (AD) is a biphasic inflammatory skin disease characterized by an initial phase predominated by T(H)2 cytokines, which switches into a second T(H)1-dominated chronic… Expand
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Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals.
A complementary DNA encoding a pollen allergen from white birch (Betula verrucosa) that was isolated from a pollen complementary DNA library with serum immunoglobulin E from a birch pollen-allergic… Expand
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Recombinant allergens promote expression of CD203c on basophils in sensitized individuals.
BACKGROUND Traditionally, the diagnosis of type I allergies is based on clinical data, skin test results, and laboratory test results with allergen extracts. During the past few years, several… Expand
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