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Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization
- R. V. van der Kwast, E. van Ingen, L. Parma, H. Peters, P. Quax, A. Nossent
- BiologyCirculation research
- 28 December 2017
The findings suggest miR487b editing plays an intricate role in postischemic neovascularization, and shows that adenosine deaminase acting on RNA 1 and 2 and fibrillarin negatively influence each other’s expression.
An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Recent findings that demonstrate that both isomiRs and microRNAs and microRNA modifications directly affect neovascularization and vascular remodeling are discussed.
MicroRNA-411 and Its 5'-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia.
Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia
Stable In Vivo Transgene Expression in Endothelial Cells with Helper-Dependent Adenovirus: Roles of Promoter and Interleukin-10.
- Nagadhara Dronadula, Bradley K. Wacker, R. V. van der Kwast, Jingwan Zhang, D. Dichek
- BiologyHuman gene therapy
- 1 March 2017
The data establish that transgene expression from HDAd in EC is inherently stable in vivo and suggest that the early decline of CMV promoter-driven expression fromHDAd-transduced EC is due neither to active downregulation of transcription nor to loss of HDAd genomes.
Genetic associations and regulation of expression indicate an independent role for 14q32 snoRNAs in Human Cardiovascular Disease.
- K. Håkansson, Eveline A. C. Goossens, A. Y. Nossent
- Biology, MedicineCardiovascular research
- 13 December 2018
14q32 snoRNAs appear to play an independent role in cardiovascular pathology and are specifically regulated throughout the human vasculature and their expression is upregulated during cardiovascular disease.
N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4
- Daphne A. L. van den Homberg, R. V. van der Kwast, P. Quax, A. Nossent
- BiologyInternational journal of molecular sciences
- 19 January 2022
Vasoactive micro RNAs are commonly m6A methylated in fibroblasts and the effect of hypoxia on microRNAs methylation is examined, which highlights the regulatory potential of the emerging field of microRNA modifications.