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Halothane inhibits agonist-induced inositol phosphate and Ca2+ signaling in A7r5 cultured vascular smooth muscle cells.
- J. Sill, C. Uhl, S. Eskuri, R. V. Van dyke, J. Tarara
- Chemistry, Medicine
- Molecular pharmacology
- 1 December 1991
In vascular smooth muscle cells, halothane alters Ca2+ homeostasis, an action that may underlie the in vivo vasodilator effects of the anesthetic. Expand
The effects of volatile anesthetics on Ca++ mobilization in rat hepatocytes.
This study provides direct evidence that in hepatocytes, intracellular Ca++ is released from internal stores by halothane, enflurane, and isoflurane. Hepatocytes isolated from rat livers were used… Expand
Halothane Impairs the Hemodynamic Influence of Endothelium‐derived Nitric Oxide
Overall, halothane blunted or blocked the systemic and regional hemodynamic responses to EDNO synthesis inhibition seen in conscious and barbiturate‐anesthetized rats, indicating that Halothane anesthesia inhibits EDNO‐mediated regulation of systemic and organ hemodynamics. Expand
Hepatic Centrilobular Necrosis in Rats after Exposure to Halothane, Enflurane, or Isoflurane
- R. V. Van dyke
- Anesthesia and analgesia
- 1 October 1982
In this study, in addition to increasing the incidence of toxicity, fasting reduced the glutathione levels and also increased cytochrome P-450 concentrations, which may be related more directly to severe hypoxia than to a direct toxic intermediate produced as a result of metabolism. Expand
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers.
Metabolism-dependent binding of the chlorinated insecticide DDT and its metabolite, DDD, to microsomal protein and lipids.
Dichlorodiphenyldichloroethane (DDD) was rapidly formed from DDT under anaerobic conditions, although when DDD was utilized as substrate, binding to microsomal protein occurred only in the presence of oxygen. Expand
Anesthesia approach to hepatic transplantation.
In the experience during the first 100 liver transplantations performed at this institution, use of a rapid infusion pump and venovenous bypass has helped normalize hemodynamic and renal function. Expand
Foreign compound metabolism studies with human liver obtained as surgical waste. Relation to donor characteristics and effects of tissue storage.
- G. Powis, I. Jardine, +7 authors C. Szumlanski
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 July 1988
Cadaver liver was a poor source of material for metabolism studies with the majority of the enzymes investigated, and the loss of activity for many of these enzymes could be simulated by keeping fresh human liver at the temperature of the body after death. Expand
Hemodynamic and metabolic changes in hepatic transplantation.
The major hemodynamic changes at the time of reperfusion of the donor liver were significant decreases in arterial blood pressure, systemic vascular resistance, and pulmonary artery temperature and significant increases in cardiac output and pulmonary capillary wedge pressure. Expand
Hepatic Oxygen Supply and Consumption in Rats Exposed to Thiopental, Halothane, Enflurane, and Isoflurane in the Presence of Hypoxia
Results show that, during exposure to mild hypoxia, a sub-MAC dose of isoflurane maintains the relationship of hepatic oxygen supply to uptake better than thiopental, halothane, or enflurane. Expand