• Publications
  • Influence
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells.
TLDR
It is shown that loss of KDM5a restores differentiation through increasing mitochondrial respiration, revealing the switch to oxidative phosphorylation as an essential step in restoring differentiation and a less aggressive cancer phenotype. Expand
Expression of Polycomb Targets Predicts Breast Cancer Prognosis
TLDR
Depletion of EZH2 in breast cancer cells significantly increased expression of the top altered genes, decreased proliferation, and improved cell adhesion, indicating a critical role played by EZh2 in determining the cancer phenotype. Expand
Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E inhibition in melanoma.
TLDR
The level of cross-resistance between combined MAPK inhibition and radiotherapy is dependent on the treatment sequence, and JARID1B may represent a novel therapy-overarching resistance marker. Expand
Honokiol is a FOXM1 antagonist
TLDR
A novel and specific mechanism for FOXM1 inhibition by honokiol is demonstrated, which partially may explain its anticancer activity in cancer cells. Expand
Application of Circulating Cell-Free Tumor DNA Profiles for Therapeutic Monitoring and Outcome Prediction in Genetically Heterogeneous Metastatic Melanoma.
TLDR
The results show the potential role of ctDNA measurement as a sensitive monitoring and prediction tool for the early assessment of disease progression and therapeutic response in patients with metastatic melanoma. Expand
Plasma Next Generation Sequencing and Droplet Digital-qPCR-Based Quantification of Circulating Cell-Free RNA for Noninvasive Early Detection of Cancer
TLDR
The findings support further validation of cfRNA detection by RT-ddPCR as a biomarker for early detection of solid cancers. Expand
A Novel Function of Molecular Chaperone HSP70
TLDR
The unique and novel mechanism of FOXM1 suppression by proteasome inhibitors is determined and it is found that HSP90 inhibitor PF-4942847 and heat shock also suppressFOXM1. Expand
Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells.
TLDR
Functionally, overexpression of KDM5B in melanoma cells led to broadening of their oxidative metabolism from mainly glutamine-dependent to additionally glucose- and fatty acid-utilizing, upregulation of the pentose phosphate pathway as a source of anti-oxidant NADPH, and maintenance of a high GSH/GSSG ratio. Expand
The predictive and prognostic significance of cell‐free DNA concentration in melanoma
TLDR
This data indicates that once a biomarker is identified, the next step in the treatment of advanced melanoma is likely to be down-regulation, which is a major concern in patients with newly diagnosed melanoma. Expand
Efficacy of cold atmospheric plasma vs. diclofenac 3% gel in patients with actinic keratoses: a prospective, randomized and rater‐blinded study (ACTICAP)
TLDR
There is a continuing need for nontoxic lesion- and field-directed treatment options for extensive actinic keratoses, and confirmatory clinical studies comparing the efficacy of CAP with conventional therapies are lacking. Expand
...
1
2
...