• Publications
  • Influence
Lipotoxic heart disease in obese rats: implications for human obesity.
To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG wasExpand
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Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.
The hormone glucagon has long been dismissed as a minor contributor to metabolic disease. Here we propose that glucagon excess, rather than insulin deficiency, is the sine qua non of diabetes. WeExpand
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Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications
We review evidence that increased tissue levels of fatty acyl CoA cause the β-cell abnormalities of nondiabetic obesity and ultimately result in obesity-dependent diabetes. Nondiabetic obesity inExpand
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Lipotoxic diseases.
  • R. Unger
  • Medicine
  • Annual review of medicine
  • 2002
I review evidence that leptin is a liporegulatory hormone that controls lipid homeostasis in nonadipose tissues during periods of overnutrition. When adipocytes store excess calories asExpand
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Leptin therapy in insulin-deficient type I diabetes
In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined with low-dose insulin reverses the catabolic state through suppression of hyperglucagonemia.Expand
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Making insulin-deficient type 1 diabetic rodents thrive without insulin
Terminally ill insulin-deficient rodents with uncontrolled diabetes due to autoimmune or chemical destruction of β-cells were made hyperleptinemic by adenoviral transfer of the leptin gene. WithinExpand
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Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early β cell compensation for insulin resistance (4-fold β cell hyperplasia) followed by decompensation (>50% loss of β cells). InExpand
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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early beta cell compensation for insulin resistance (4-fold beta cell hyperplasia) followed by decompensation (>50% loss of beta cells). InExpand
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Novel Form of Lipolysis Induced by Leptin*
Hyperleptinemia causes disappearance of body fat without a rise in free fatty acids (FFA) or ketones, suggesting that leptin can deplete adipocytes of fat without releasing FFA. To test this, weExpand
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Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.
A recently identified function of leptin is to protect nonadipose tissues from the nonoxidative metabolic products of long-chain fatty acids (FAs) during periods of overnutrition by increasing theExpand
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