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Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells
TPD52 plays an important role in various molecular events, particularly in the morphological diversification and dissemination of prostate carcinoma cells, and may be a promising target with respect to developing new therapeutic strategies to treat prostate cancer.
Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer.
Identification of Clinically Relevant Protein Targets in Prostate Cancer with 2D-DIGE Coupled Mass Spectrometry and Systems Biology Network Platform
Compared the individual protein expression patterns from histologically characterized PCa and the surrounding benign tissue obtained by manual micro dissection using highly sensitive two-dimensional differential gel electrophoresis (2D-DIGE) coupled with mass spectrometry revealed novel proteins and molecular networks with altered expression in PCa.
Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation
It is proposed that UCHL1 downregulation via promoter hypermethylation plays an important role in various molecular aspects of PCa biology, such as morphological diversification and regulation of proliferation.
Repurposing of a drug scaffold: Identification of novel sila analogues of rimonabant as potent antitubercular agents.
Stereotypical Chronic Lymphocytic Leukemia B-Cell Receptors Recognize Survival Promoting Antigens on Stromal Cells
CLL BCR stimulation by stroma-derived antigens can contribute to the protective effect that the stroma exerts on CLL cells, which sheds a new light on the understanding of the pathobiology of this so far mostly incurable disease.
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.
Links between the control of systemic iron homeostasis and critical liver processes such as regeneration, response to injury, carcinogenesis, and nutrient metabolism are identified using a combination of RNAi screening, reverse phase protein arrays, and small molecules testing.
Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.
Functional characterization of PRDX3 and PRDX4 activity in PCa cell lines suggests a role of these members of the peroxiredoxin family in the pathophysiology of this tumor entity.
Statin‐induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms
It is concluded that fluvastatin, by altering iron homeostasis, nitric oxide generation and antioxidant defence mechanisms, induces triple negative breast cancer cell death.
Tumor protein D52 (isoform 3) contributes to prostate cancer cell growth via targeting nuclear factor-κB transactivation in LNCaP cells
- Chandrashekhar Dasari, Dattu Prasad Yaghnam, R. Walther, R. Ummanni
- Biology, ChemistryTumour biology : the journal of the International…
- 1 April 2017
Mechanistically, it is found that TPD52 confers transactivation of nuclear factor-κB, thereby enhancing its target gene expression in LNCaP cells and highlighting the approach for therapeutic targeting of T PD52 in prostate cancer.