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CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS. Expand
Toll-like receptors in the induction of the innate immune response
A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence. Expand
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)
It is demonstrated that p38, like JNK, is activated by treatment of cells with pro-inflammatory cytokines and environmental stress and the mechanism of p38 activation is mediated by dual phosphorylation on Thr-180 and Tyr-182. Expand
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.
Findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress. Expand
Structure and function of lipopolysaccharide binding protein.
The identification of this pathway for LPS-induced monocyte stimulation may aid in the development of treatments for diseases in which Gram-negative sepsis or endotoxemia are involved. Expand
BMK1/ERK5 regulates serum‐induced early gene expression through transcription factor MEF2C
A constitutively active form of the MAP kinase kinase, MEK5(D), is described, which selectively activates BMK1 but not other MAP kinases in vivo, and results strongly suggest that in some cell types theMEK5/BMK1 MAP Kinase signaling pathway regulates serum‐induced early gene expression through the transcription factor MEF2C. Expand
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin.
How LBP enables LPS binding to CD14 and how complexes of LPS and soluble or GPI-anchored CD14 participate in cell activation are discussed, and the evidence supporting a model for a functional LPS receptor of myeloid cells, which is multimeric, is reviewed. Expand
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
The results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection, and a link between the p38 pathway and a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors is demonstrated. Expand
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.
It is shown that soluble CD14 (sCD14) is required for activation of endothelial and epithelial cells by LPS, and it is proposed that LPS-LBP complexes transfer LPS to sCD14, and the L PS-s CD14 complexes then bind to a cellular receptor. Expand
Regulation of the MEF2 Family of Transcription Factors by p38
  • Ming Zhao, L. New, +6 authors Jiahuai Han
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1 January 1999
The results demonstrate that the MAP kinase signaling pathway can discriminate between different MEF2 isoforms and can regulate MEF 2-dependent genes through posttranslational activation of preexisting MEf2 protein. Expand