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Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits
Evidence of marked variability in response among people exposed to the same environmental risk implies that individual differences in genetic susceptibility might be at work. The study of suchExpand
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The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis
Gene–environmental interaction (G × E) between a common functional polymorphism in the promoter region of the serotonin transporter gene (5-HTT) and environmental adversity on the onset of depressionExpand
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis basedExpand
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Medial prefrontal cortex activity associated with symptom provocation in eating disorders.
OBJECTIVE The authors sought to identify neural correlates of eating disorders in order to contribute to the debate on the genesis and classification of eating disorders and provide endophenotypesExpand
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A mega-analysis of genome-wide association studies for major depressive disorder
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWASExpand
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Functional Neuroanatomy of Body Shape Perception in Healthy and Eating-Disordered Women
BACKGROUND Abnormalities in perception and evaluation of body shape are a hallmark of eating disorders. METHODS Brain responses to line drawings of underweight, normal weight, and overweight femaleExpand
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Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis.
OBJECTIVES Evidence suggests that childhood maltreatment may negatively affect not only the lifetime risk of depression but also clinically relevant measures of depression, such as course of illnessExpand
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Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.
CONTEXT A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adultExpand
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Recovery and chronicity in anorexia nervosa: brain activity associated with differential outcomes
BACKGROUND The course of anorexia nervosa varies from rapid recovery to a chronic debilitating illness. This study aimed to identify functional neural correlates associated with differentialExpand
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The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update
An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development ofExpand
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