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Defensive Bacteriome Symbiont with a Drastically Reduced Genome
It is reported that Profftella is a defensive symbiont presumably of an obligate nature with an extremely streamlined genome, suggesting their ancient and mutually indispensible association with the host. Expand
Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.
A combination of HPLC using ODS, GS320, and Phenylhexyl stationary phases permitted the purification without using acid or inorganic additives in the mobile phase of Azaspiracid-2 to exhibit potent cytotoxicity against P388 cells. Expand
Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis.
Three new antiprotozoan compounds,gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis and showed antimalarial activity against Plasmodium falciparum and also showed antileishmanial activity. Expand
Insights into the Planktothrix genus: Genomic and metabolic comparison of benthic and planktic strains
The genome of planktic and non planktic Planktothrix strains were sequenced to better represent this genus diversity and life style at the genomic level and unexpected characteristics such as buoyancy, nitrogen fixation capacity and unique natural product features were showed. Expand
Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms.
The data indicate that this polyketide family is bacteria-derived and that the unusual macrolide diversity is the result of combinatorial pathway modularity for some compounds and of convergent evolution for others. Expand
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome
Natural product biosynthesis gene clusters were identified in bacterial isolates from the Arabidopsis phyllosphere, including inhibitory products with antibiotic activity, demonstrating the potential of thephyllosphere as a resource for antibiotics. Expand
Automated structure prediction of trans-acyltransferase polyketide synthase products
TransATor is a versatile bio- and chemoinformatics web application that suggests informative chemical structures for even highly aberrant trans-AT PKS biosynthetic gene clusters, enabling the characterization of new polyketide natural products from (unusual) bacterial sources. Expand
Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor.
It is shown that colibactin formation involves a rare aminomalonyl unit used as a building block in E. coli metabolite colibactsin. Expand
Cell differentiation inducers from a marine sponge Biemna sp.
Abstract Two pyridoacridines closely related to the known isocystodamine were isolated from the marine sponge Biemna sp. together with isocystodamine. Their structures were determined on the basis ofExpand