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Plant cell cultures for the production of recombinant proteins
The use of whole plants for the synthesis of recombinant proteins has received a great deal of attention recently because of advantages in economy, scalability and safety compared with traditionalExpand
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Molecular farming in plants: host systems and expression technology.
Plants provide an inexpensive and convenient system for the large-scale production of valuable recombinant proteins. This principle has been demonstrated by the commercial success of severalExpand
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Plant-based production of biopharmaceuticals.
Plants are now gaining widespread acceptance as a general platform for the large-scale production of recombinant proteins. The first plant-derived recombinant pharmaceutical proteins are reaching theExpand
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Linear transgene constructs lacking vector backbone sequences generate low-copy-number transgenic plants with simple integration patterns
Whole plasmids are used in both Agrobacterium-mediated transformation and direct DNA transfer, generally leading to the integration of vector backbone sequences into the host genome along with theExpand
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Bacillus thuringiensis: a century of research, development and commercial applications.
Bacillus thuringiensis (Bt) is a soil bacterium that forms spores during the stationary phase of its growth cycle. The spores contain crystals, predominantly comprising one or more Cry and/or CytExpand
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Molecular characterization of transforming plasmid rearrangements in transgenic rice reveals a recombination hotspot in the CaMV 35S promoter and confirms the predominance of microhomology mediated
The characterization of plasmid-genomic DNA junctions following plant transformation has established links between DNA double-strand break repair (DSBR), illegitimate recombination and plasmid DNAExpand
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Opportunities for recombinant antigen and antibody expression in transgenic plants--technology assessment.
Plants are now gaining widespread acceptance as a general platform for the large-scale production of recombinant proteins. The principle has been demonstrated by the success of a diverse repertoireExpand
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Pharma-Planta: road testing the developing regulatory guidelines for plant-made pharmaceuticals
Significant advances over the last few years have seen plant-made pharmaceuticals (PMPs) move from the exploratory research phase towards clinical trials, with the first commercial products for humanExpand
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Effect of ethylene, intermittent warming and controlled atmosphere on postharvest quality and the occurrence of woolliness in peach (Prunus persica cv. Chiripá) during cold storage
Abstract The loss of quality in peach (Prunus persica) after harvest is associated with metabolic changes, mechanical damage, loss of pulp firmness, physiological disorders and decay. In theExpand
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GMP issues for recombinant plant-derived pharmaceutical proteins.
Recombinant proteins can be produced in a diverse array of plant-based systems, ranging from whole plants growing in the soil to plant suspension cells growing in a fully-defined synthetic medium inExpand
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