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Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo. Expand
Neuronal Networks of the Hippocampus
From the Publisher: The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons… Expand
A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances.
After these alterations, tonic depolarization of the soma leads to adapting repetitive firing, whereas stimulation of the distal dendrites leads to bursting, and a critical set of parameters concerns the regulation of the pool of intracellular [Ca2+] that interacts with membrane channels (gK(C) and gK(AHP)), particularly in the dendrite. Expand
Inhibition-based rhythms: experimental and mathematical observations on network dynamics.
- M. Whittington, R. Traub, N. Kopell, B. Ermentrout, E. Buhl
- Psychology, Medicine
- International journal of psychophysiology…
- 1 December 2000
This review will provide the reader with a brief outline of the basic properties of inhibition-based oscillations in the CNS by combining research from laboratory models, large-scale neuronal network simulations, and mathematical analysis. Expand
Analysis of gamma rhythms in the rat hippocampus in vitro and in vivo.
- R. Traub, M. Whittington, S. B. Colling, G. Buzsáki, J. Jefferys
- Biology, Medicine
- The Journal of physiology
- 1 June 1996
The data suggest that gamma‐frequency EEG activity arises in the hippocampus when pools of interneurones receive a tonic or slowly varying excitation, and on the parameters regulating the inhibitory coupling between the interneeurones. Expand
Gamma rhythms and beta rhythms have different synchronization properties.
- N. Kopell, G. Ermentrout, M. Whittington, R. Traub
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 February 2000
A simplified model is used to show that the different rhythms in the CA1 region of the hippocampus employ different dynamical mechanisms to synchronize, based on different ionic currents, which are consistent with data suggesting that gamma rhythms are used for relatively local computations whereas beta rhythms are use for higher level interactions involving more distant structures. Expand
Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro
It is reported that high-frequency network oscillations are present in rat brain slices in vitro, occurring as a brief series of repetitive population spikes at 150–200 Hz in all hippocampal principal cell layers. Expand
A mechanism for generation of long-range synchronous fast oscillations in the cortex
It is shown that in rat hippocampal slices interneurons do indeed fire spike doublets under conditions in which gamma oscillations are synchronized over several millimetres, whereas they fire single spikes under other conditions. Expand
Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro
A division of labour appears to exist whereby different frequencies and spatiotemporal properties of hippocampal rhythms are mediated by different interneurone subtypes. Expand
Axo-Axonal Coupling A Novel Mechanism for Ultrafast Neuronal Communication
The data suggest that hippocampal neurons are coupled by axo-axonal junctions, providing a novel mechanism for very fast electrical communication. Expand