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Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila
In mammals, members of the tumor necrosis factor (TNF) family play an important role in the regulation of cellular proliferation, differentiation and programmed cell death. We describe isolation andExpand
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Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a multifunctional compound, which catalyzes several essential reactions for the protection of cellular componentsExpand
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Histone Deacetylases RPD3 and HOS2 Regulate the Transcriptional Activation of DNA Damage-Inducible Genes
ABSTRACT DNA microarray and genetic studies of Saccharomyces cerevisiae have demonstrated that histone deacetylases (HDACs) are required for transcriptional activation and repression, but theExpand
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Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target☆
Ebselen is a synthetic, lipid‐soluble seleno‐organic compound. The high electrophilicity of ebselen enables it to react with multiple cysteine residues of various proteins. Despite extensive researchExpand
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Unexpected Histone H3 Tail-clipping Activity of Glutamate Dehydrogenase*
Background: Histone H3 clipping has been reported in chicken liver tissues and not in brain. Results: Glutamate dehydrogenase (GDH) is a histone H3-specific protease that clips free andExpand
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Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes
Rap1 (repressor‐activator protein 1) is a multifunctional protein that controls telomere function, silencing and the activation of glycolytic and ribosomal protein genes. We have identified a novelExpand
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New Quasi-Static Models for the Computer-Aided Design of Suspended and Inverted Microstrip Lines (Short Paper)
New quasi-static models for the computer-aided design (CAD) and analysis of open suspended and inverted microstrip lines are reported. The models are obtained through generalizing those reportedExpand
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A Novel Mechanism of Antagonism between ATP-Dependent Chromatin Remodeling Complexes Regulates RNR3 Expression
ABSTRACT Gene expression depends upon the antagonistic actions of chromatin remodeling complexes. While this has been studied extensively for the enzymes that covalently modify the tails of histones,Expand
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Genetic variability in ginger (Gingiber officinale Roscoe.)
The genetic coefficient of variation, heritability and genetic advance were assessed in 16 genotypes of ginger. The differences between the genotypes were highly significant for all the charactersExpand
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Use of adeno-associated viral vector for delivery of small interfering RNA
Post-transcriptional gene silencing by small interfering RNAs (siRNAs) is rapidly becoming a powerful tool for genetic analysis of mammalian cells. Delivery of siRNA into mammalian cells is usuallyExpand
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