• Publications
  • Influence
Habituation: a model phenomenon for the study of neuronal substrates of behavior.
An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free
Habituation: a dual-process theory.
Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response.
The data show that early in training, and well before any CRs occurred, there was a substantial increase in neuronal activity in the hippocampus that began during the CS and persisted through the trace interval and formed a model of the amplitude-time course of the behavioral CR.
Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.
The effects of stress on subsequent LTP and LTD appear to be mediated through the activation of the NMDA subtype of glutamate receptors, which modifications in hippocampal plasticity may contribute to learning and memory impairments associated with stress.
Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses.
The hippocampus appears to be necessary for the retention of recently acquired, but not remotely acquired, trace conditioned responses in rabbits.
Cerebellum: essential involvement in the classically conditioned eyelid response.
The dentate-interpositus nuclei were concluded to be critically involved in the learning and production of classically conditioned responses.
The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus.
Estrogen replacement therapy in women is associated with improvement of cognitive deficits and reduced incidence of Alzheimer's disease, and estrogen is neuroprotective against N-methyl-d-aspartate- and kainate-mediated neurotoxicity, an effect mediated by tyrosine kinase/mitogen-activated protein kinase (MAPK) pathways.
17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation.
In vitro hippocampal slices from 2-mo-old Sprague-Dawley male rats were used to demonstrate that estrogen enhances NMDA receptor-mediated currents and promotes an enhancement of LTP magnitude.
The search for the engram.
  • R. Thompson
  • Biology, Psychology
    The American psychologist
  • 1 March 1976
This chapter focuses on learning and memory and its neural bases and examines the ways in which temporal, logical, and qualitative relationships between stimuli (CS and US) influence learning.