Share This Author
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of patients with Alzheimer's disease and 9 neuropathologically normal subjects reveal very powerful correlations with all three psychological assays.
Pathological verification of ischemic score in differentiation of dementias
Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and who…
Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase
- D. Armstrong, C. Saper, A. Levey, B. Wainer, R. Terry
- BiologyThe Journal of comparative neurology
- 1 May 1983
The correspondence of the distribution of ChAT‐labeled neurons identified by the methods to earlier immunocytochemical and acetylcholinesterase histochemical studies and to connectional studies of these groups argues for the specificity of the ChAT antibody used.
Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
The unexpected findings in these subjects were higher brain weights and greater number of neurons as compared to age‐matched nursing home control subjects, which suggest people may have had incipient Alzheimer's disease but escaped loss of large neurons, or started with larger brains and more large neurons and thus might be said to have had a greater reserve.
ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.
An electron microscopic study of cerebral biopsy specumens from 3 cases of Alzheimer's presenile dementia has revealed several points of interest, including certain myelin distortions suggestive of primary demyelinization; and a striking, although rare, endothelial change by which lipid-like material passes through the walls of small vessels to enter the lumen.
Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.
The guidelines presented are adapted from those used by many neuropathologists at Alzheimer's disease research centers participating in CERAD, the Consortium to Establish a Registry for Alzheimer's Disease.
Neocortical cell counts in normal human adult aging
Aging affects the frontal and temporal lobes more than the parietal; the salient change is shrinkage of large neurons with consequently increasing numbers of small neurons in the midfrontal and superior temporal areas.
Spectrum of human immunodeficiency virus–associated neocortical damage
- E. Masliah, C. Achim, N. Ge, R. DeTeresa, R. Terry, C. Wiley
- Biology, MedicineAnnals of neurology
- 1 September 1992
In a subset of 23 AIDS autopsies during which short postmortem times and absence of significant opportunistic infection permitted quantitative analysis of dendritic and synaptic complexities, a strong correlation between neocortical dendrite and presynaptic damage and abundance of HIV envelope protein in the neocorticals gray and deep white matter is identified.
Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa
Results obtained with a RIA for somatostatin are reported, showing that som atostatin-like immunoreactivity in the cerebral cortex is reduced in tissue from AD/SDAT patients.
THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE
- R. Terry
- MedicineJournal of neuropathology and experimental…
- 1 October 1963