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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of patients with Alzheimer's disease and 9 neuropathologically normal subjects reveal very powerful correlations with all three psychological assays. Expand
Pathological verification of ischemic score in differentiation of dementias
Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and whoExpand
Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
The unexpected findings in these subjects were higher brain weights and greater number of neurons as compared to age‐matched nursing home control subjects, which suggest people may have had incipient Alzheimer's disease but escaped loss of large neurons, or started with larger brains and more large neurons and thus might be said to have had a greater reserve. Expand
Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase
The correspondence of the distribution of ChAT‐labeled neurons identified by the methods to earlier immunocytochemical and acetylcholinesterase histochemical studies and to connectional studies of these groups argues for the specificity of the ChAT antibody used. Expand
Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.
The guidelines presented are adapted from those used by many neuropathologists at Alzheimer's disease research centers participating in CERAD, the Consortium to Establish a Registry for Alzheimer's Disease. Expand
Spectrum of human immunodeficiency virus–associated neocortical damage
In a subset of 23 AIDS autopsies during which short postmortem times and absence of significant opportunistic infection permitted quantitative analysis of dendritic and synaptic complexities, a strong correlation between neocortical dendrite and presynaptic damage and abundance of HIV envelope protein in the neocorticals gray and deep white matter is identified. Expand
Neocortical cell counts in normal human adult aging
Aging affects the frontal and temporal lobes more than the parietal; the salient change is shrinkage of large neurons with consequently increasing numbers of small neurons in the midfrontal and superior temporal areas. Expand
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Image analysis apparatus was used to count and measure glial and neuronal perikarya in ten size classes in the midfrontal region and superior temporal gyrus of 18 patients with senile dementia of theExpand
Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat
It is concluded that GAP-43 may play a role in the synaptic remodeling that occurs in the denervated rat hippocampus and that quantitative morphometry of synaptophysin immunolabeling accurately reflects the fate of presynaptic terminals in this model of degeneration and reinnervation. Expand