• Publications
  • Influence
Palladium-catalyzed reactions of cyclohexadienones: regioselective cyclizations triggered by alkyne acetoxylation.
TLDR
The predictable regioselectivity of these atom-economical and stereoselective reactions is influenced by developing steric interactions during migratory insertion of a vinyl palladium intermediate.
Ligand and substrate effects during Pd-catalyzed cyclizations of alkyne-tethered cyclohexadienones.
TLDR
The effects of ligand and substrate choice on the Pd-catalyzed cyclization of alkyne-tethered cyclohexadienones were examined and the enantioselectivity of the desymmetrization is remarkably sensitive to structural changes in both the lig and the substrate.
Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.
TLDR
A series of structurally simplified cryptocaryone analogues synthesized by a facile Pd-catalyzed acetoxylation of alkyne-tethered cyclohexadienones constitute a promising new scaffold for the development of novel NF-κB inhibitors and anticancer agents.
Regioselective and stereoselective cyclizations of cyclohexadienones tethered to active methylene groups.
TLDR
By using a Cinchona alkaloid-based phase-transfer catalyst, prochiral cyclohexadienones can be desymmetrized with moderate stereoselectivity and give highly unusual electron-deficient tricyclic cyclopropanes.
Design, synthesis, and evaluation of cystargolide-based β-lactones as potent proteasome inhibitors.
TLDR
The novel drug lead 5k is a more potent proteasome inhibitor than carfilzomib with mid-to-low nanomolar IC50 measurements and it is cytotoxic against multiple cancer cell lines at levels approaching those of carfilZomib.
Evolution of a protecting-group-free total synthesis: studies en route to the neuroactive marine macrolide (-)-palmyrolide A.
TLDR
A full account of the synthetic work toward the first total synthesis of the neuroactive marine macrolide (-)-palmyrolide A is described, with the result that the first protecting-group-freetotal synthesis of natural (-)-Palmyrolides A is reported.
Asymmetric total synthesis and absolute stereochemistry of the neuroactive marine macrolide palmyrolide A.
TLDR
The first asymmetric total synthesis and determination of the absolute configuration for the neuroactive marine macrolide palmyrolide A is described and comparison with the authentic spectral data confirms the synthesis of (+)-ent-palmyrolides A.
A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications.
TLDR
Overall, the results highlight that some of the degradation products of ibuprofen can be more toxic to human kidney cell line and liver cell line than the parent compound while ib uprofenCan be more Toxic to human gut microbiota and A. fischeri than ibup rofen degradation products.
Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B.
TLDR
Evaluation of synthetic cystargolides and derivatives showed that the natural (2S,3R) stereochemistry is essential for activity, and benzyl esters (-)-10 and (-)-15 were found to be about 100 times more potent, and to selectively kill MCF-7 cancerous cells.
A formal synthesis of the auriside aglycon.
A highly convergent formal synthesis of the auriside aglycon was achieved. An indene-based thiazolidinethione chiral auxiliary was used for the construction of both the C1-C9 and C10-C17 fragments
...
1
2
3
...