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Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
It is demonstrated that curcumin-loaded PLGA nanoparticles formulation has enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo overCurcumin. Expand
Tissue-specific synthesis and oxidative metabolism of estrogens.
- C. Jefcoate, J. Liehr, +10 authors L. Berstein
- Journal of the National Cancer Institute…
- 1 July 2000
Evidence in support of the role of P4501B1 as the 4-hydroxylase expressed in human breast tissue is reviewed and the hypothesis that sufficient E2 may be present in tissue for formation of catechol metabolites that are estrogenic and which form genotoxic species at levels that may contribute to estrogen carcinogenesis is questioned. Expand
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
- Jayaraj Ravindran, H. Nair, B. Sung, S. Prasad, R. Tekmal, B. Aggarwal
- Chemistry, Medicine
- Biochemical pharmacology
- 1 June 2010
The results demonstrate that encapsulation of TQ into nanoparticles enhances its anti-proliferative, anti-inflammatory, and chemosensitizing effects. Expand
Induction of aromatase expression in cervical carcinomas: effects of endogenous estrogen on cervical cancer cell proliferation.
To the knowledge, this is the first report demonstrating the induction of aromatase expression in cervical carcinomas, and opens the possibility that aromat enzyme inhibitors may be potential therapeutic agents in cervical cancer cells expressing aromatases. Expand
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor‐α target gene activation by regulating lysine demethylase 1 specificity
Results suggest that PELP1 is a reader of H3 methylation marks and has a crucial role in modulating the histone code at the ERα target genes. Expand
Therapeutic Significance of Estrogen Receptor β Agonists in Gliomas
- G. Sareddy, B. Nair, +5 authors R. Vadlamudi
- Biology, Medicine
- Molecular Cancer Therapeutics
- 21 March 2012
The results suggest that ERβ signaling has a tumor-suppressive function in gliomas, and identification of an ERβ agonist as a therapeutic agent can be readily extended to clinical use with current chemotherapies, providing an additional tool for enhancing survival inglioma patients. Expand
A phosphotyrosine switch determines the antitumor activity of ERβ.
- Bin Yuan, Long Cheng, +16 authors Rong Li
- Biology, Medicine
- The Journal of clinical investigation
- 1 August 2014
It is shown that phosphorylation of a tyrosine residue present in ERβ, but not in ERα, dictates ERβ-specific activation of transcription and is required for ER β-dependent inhibition of cancer cell growth in culture and in murine xenografts. Expand
Significance of PELP1 in ER-Negative Breast Cancer Metastasis
- S. Roy, D. Chakravarty, +7 authors R. Vadlamudi
- Medicine, Biology
- Molecular Cancer Research
- 15 November 2011
PELP1 knockdown reduced the in vivo metastatic potential of ER-negative breast cancer cells and significantly reduced lung metastatic nodules in a xenograft assay, and a novel mechanism of coregulator regulation of metastasis via promoting cell motility/EMT by modulating expression of genes is revealed. Expand
Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers
This first-in-class agent, with its novel mechanism of action of disrupting critical protein-protein interactions, overcomes the limitations of current therapies and may be clinically translatable for patients with therapy-sensitive and therapy-resistant breast cancers. Expand
Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression--clinicopathological correlation.
The study on macrophages offers a potential approach for cervical cancer treatment, since macrophage count is closely related to progression of CIN, and can be used as an applicable marker of such a risk. Expand