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The chick embryo in toxicology: an alternative to the rabbit eye.
- J. Leighton, J. Nassauer, R. Tchao
- Chemistry, Medicine
- Food and chemical toxicology : an international…
- 1 February 1985
The chorioallantoic membrane (CAM) of the chick embryo is readily accessible for experimentation. It is a complete tissue that responds to injury with classical inflammatory reactions. It is limited… Expand
Effect of Processing Methods and Heat Treatment on the Formation of Wax Matrix Tablets for Sustained Drug Release
- Y. Zhang, R. Tchao, J. B. Schwartz
- Chemistry, Medicine
- Pharmaceutical development and technology
- 1 January 2001
The objective of this study was to evaluate the effects of processing methods and heat treatment on matrix formation and subsequent drug release from wax matrix tablets for controlled release.… Expand
Effect of gender, dose, and time on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT)-induced hepatotoxicity in Fischer 344 rats.
- N. Patel, C. M. Crincoli, E. L. Kennedy, D. M. Frederick, R. Tchao, P. J. Harvison
- Xenobiotica; the fate of foreign compounds in…
1. The thiazolidinedione ring present in drugs available for type II diabetes can contribute to hepatic injury. Another thiazolidinedione ring-containing compound,… Expand
Maturational changes in CYP2D16 expression and xenobiotic metabolism in adrenal glands from male and female guinea pigs.
- B. Yuan, R. Tchao, J. M. Voigt, H. Colby
- Medicine, Biology
- Drug metabolism and disposition: the biological…
- 1 February 2001
CYP2D16 is expressed at high levels in the zona reticularis (ZR) of guinea pig adrenal glands and contributes to adrenal metabolism of xenobiotics. Studies were done to evaluate the effects of age… Expand
Angiogenesis-dependent tumor spread in reinforced fibrin clot culture.
To investigate the role played by developing microvessels in the spread of tumors, segments of rat aorta were cultured with aggregates of NBT-II-81, a cell line derived from squamous cell carcinoma… Expand
Hemicyst formation stimulated by cyclic AMP in dog kidney cell line MDCK
Certain epithelial cell lines have morphologic, physiologic, biochemical and pharmacologic characteristics of transporting epithelia from intact organs. In this paper we show that dibutyryl cyclic… Expand
Interactions of tumor cells with human amnion membrane: a model for studying tumor invasion in vitro.
The human amnion membrane consisting of a single layer of epithelium attached to the continuous basement membrane and the underlying collagenous stroma has been used to study tumor invasion in vitro… Expand
Histotypic angiogenesis in vitro: Light microscopic, ultrastructural, and radioautographic studies
SummaryA model for the study of angiogenesis in vitro is described. Rat aortas, cultured in a tridimensional matrix of clotted chick plasma, gave rise to luxuriant outgrowth of vascular channels. We… Expand
Use of a Human Corneal Epithelial Cell Line for Screening the Safety of Contact Lens Care Solutions In Vitro
- D. McCanna, K. Harrington, Jean-Yves Driot, K. Ward, R. Tchao
- Eye & contact lens
- 1 January 2008
Purpose. Sodium fluorescein permeability assay, alamarBlue assay, and scanning electron microscopy were performed to study the effects of various contact lens disinfecting multipurpose solutions… Expand
Comparison of contact lens multipurpose solutions by in vitro sodium fluorescein permeability assay.
- R. Tchao, D. McCanna, M. Miller
- Medicine, Chemistry
- The CLAO journal : official publication of the…
- 1 July 2002
PURPOSE This article reports the use of in vitro sodium fluorescein permeability assay to study the effects of various contact lens disinfecting solutions on the integrity of epithelium. METHODS We… Expand