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Microtubule Minus-End Binding Protein CAMSAP2 Controls Axon Specification and Dendrite Development
In neurons, most microtubules are not associated with a central microtubule-organizing center (MTOC), and therefore, both the minus and plus-ends of these non-centrosomal microtubules are foundExpand
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New constraints on oscillation parameters from v(e) appearance and v(mu) disappearance in the NOvA experiment
For full abstract please refer to Official URL link”, or if there is a document attached which contains the abstract, “For full abstract please refer to attached document
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MICAL3 Flavoprotein Monooxygenase Forms a Complex with Centralspindlin and Regulates Cytokinesis*
During cytokinesis, the antiparallel array of microtubules forming the central spindle organizes the midbody, a structure that anchors the ingressed cleavage furrow and guides the assembly ofExpand
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Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport
Summary Microtubules are essential for polarized transport in neurons, but how their organization guides motor proteins to axons or dendrites is unclear. Because different motors recognize distinctExpand
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A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large
BackgroundAffinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identificationExpand
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Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment
The selective transport of different cargoes into axons and dendrites underlies the polarized organization of the neuron. Although it has become clear that the combined activity of different motorsExpand
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TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment
Selective cargo transport into axons and dendrites over the microtubule network is essential for neuron polarization. The axon initial segment (AIS) separates the axon from the somatodendriticExpand
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Three-Step Model for Polarized Sorting of KIF17 into Dendrites
Kinesin and dynein motors drive bidirectional cargo transport along microtubules and have a critical role in polarized cargo trafficking in neurons [1, 2]. The kinesin-2 family protein KIF17 is aExpand
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Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry
In neurons, microtubules form dense bundles and run along the length of axons and dendrites. Occasionally, dendritic microtubules can grow from the shaft directly into dendritic spines. MicrotubulesExpand
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Feedback-Driven Assembly of the Axon Initial Segment
Summary The axon initial segment (AIS) is a unique neuronal compartment that plays a crucial role in the generation of action potential and neuronal polarity. The assembly of the AIS requiresExpand
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