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BMK1/ERK5 regulates serum‐induced early gene expression through transcription factor MEF2C
Big MAP kinase 1 (BMK1), also known as ERK5, is a mitogen‐activated protein (MAP) kinase member whose biological role is largely undefined. We have shown previously that the activity of BMK1 in ratExpand
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Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
Leptospira interrogans are zoonotic pathogens that have been linked to a recent increased incidence of morbidity and mortality in highly populated tropical urban centers. They are unique amongExpand
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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
Epidermal growth factor (EGF) induces cell proliferation in a variety of cell types by binding to a prototype transmembrane tyrosine kinase receptor,. Ligation of this receptor by EGF activates Erk1Expand
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Cutting Edge: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects against Leprosy1
TLRs constitute an essential family of pattern recognition molecules that, through direct recognition of conserved microbial components, initiate inflammatory responses following infection. In thisExpand
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Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor for Escherichia and Salmonella Lipopolysaccharides1
Two members of the mammalian Toll-like receptor (TLR) family, TLR2 and TLR4, have been implicated as receptors mediating cellular activation in response to bacterial LPS. Through the use of mAbsExpand
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Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1*
Toll-like receptor 4 (TLR4) and TLR2 agonists from bacterial origin require acylated saturated fatty acids in their molecules. Previously, we reported that TLR4 activation is reciprocally modulatedExpand
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Binding of Bacterial Peptidoglycan to CD14*
The hypothesis that soluble peptidoglycan (sPGN, a macrophage-activator from Gram-positive bacteria) binds to CD14 (a lipopolysaccharide (LPS) receptor) was tested. sPGN specifically bound to CD14 inExpand
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Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling
TLRs are central receptors of the innate immune system that drive host inflammation and adaptive immune responses in response to invading microbes. Among human TLRs, TLR10 is the only family memberExpand
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Big Mitogen-activated Kinase Regulates Multiple Members of the MEF2 Protein Family*
Big mitogen-activated protein (MAP) kinase (BMK1), a member of the mammalian MAP kinase family, is activated by growth factors. The activation of BMK1 is required for growth factor-induced cellExpand
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MEKK3 Directly Regulates MEK5 Activity as Part of the Big Mitogen-activated Protein Kinase 1 (BMK1) Signaling Pathway*
Big mitogen-activated protein (MAP) kinase (BMK1), also known as ERK5, is a member of the MAP kinase family whose cellular activity is elevated in response to growth factors, oxidative stress, andExpand
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