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- Publications
- Influence
Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry.
- B. Luo, K. Groenke, R. Takors, C. Wandrey, M. Oldiges
- Chemistry, Medicine
- Journal of chromatography. A
- 20 April 2007
A highly selective and sensitive method for identification and quantification of intracellular metabolites involved in central carbon metabolism (including glycolysis, pentose phosphate pathway and… Expand
Quantification of intracellular metabolites in Escherichia coli K12 using liquid chromatographic-electrospray ionization tandem mass spectrometric techniques.
- A. Buchholz, R. Takors, C. Wandrey
- Medicine, Chemistry
- Analytical biochemistry
- 15 August 2001
The quantitative comprehension of microbial metabolic networks is a prerequisite for an efficient rational strain improvement ("metabolic engineering"). It is therefore necessary to accurately… Expand
Automated sampling device for monitoring intracellular metabolite dynamics.
- U. Schäfer, W. Boos, R. Takors, D. Weuster-Botz
- Chemistry, Medicine
- Analytical biochemistry
- 15 May 1999
An automated sampling device coupled to a stirred tank reactor was developed for monitoring intracellular metabolite dynamics. Sample flasks fixed in transport magazines were moved by a step engine… Expand
Metabolomics: quantification of intracellular metabolite dynamics.
- A. Buchholz, J. Hurlebaus, C. Wandrey, R. Takors
- Biology, Medicine
- Biomolecular engineering
- 1 June 2002
The rational improvement of microbial strains for the production of primary and secondary metabolites ('metabolic engineering') requires a quantitative understanding of microbial metabolism. A… Expand
Scale-up of microbial processes: impacts, tools and open questions.
- R. Takors
- Computer Science, Medicine
- Journal of biotechnology
- 31 July 2012
TLDR
Recombinant Protein Production with Pichia pastoris in Continuous Fermentation – Kinetic Analysis of Growth and Product Formation
- S. Curvers, Jorg Linnemann, T. Klauser, C. Wandrey, R. Takors
- Chemistry
- 1 December 2001
Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments.
- K. Nöh, K. Groenke, B. Luo, R. Takors, M. Oldiges, W. Wiechert
- Chemistry, Medicine
- Journal of biotechnology
- 30 April 2007
A novel approach to (13)C metabolic flux analysis (MFA) is presented using cytosolic metabolite pool sizes and their (13)C labeling data from an isotopically non-stationary (13)C labeling experiment… Expand
Platform Engineering of Corynebacterium glutamicum with Reduced Pyruvate Dehydrogenase Complex Activity for Improved Production of l-Lysine, l-Valine, and 2-Ketoisovalerate
- J. Buchholz, A. Schwentner, +6 authors Bastian Blombach
- Biology, Medicine
- Applied and Environmental Microbiology
- 8 July 2013
ABSTRACT Exchange of the native Corynebacterium glutamicum promoter of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex (PDHC), with mutated dapA promoter variants led to… Expand
Fed‐Batch Process for Pyruvate Production by Recombinant Escherichia coli YYC202 Strain
- B. Zelić, Tanja Gerharz, M. Bott, Đ. Vasić-Rački, C. Wandrey, R. Takors
- Chemistry, Biology
- 9 July 2003
Fed‐batch fermentation was applied to the production of pyruvate by using a recombinant Escherichia coli YYC202 strain. This strain is completely blocked in its ability to convert pyruvate into… Expand
Genome reduction boosts heterologous gene expression in Pseudomonas putida
- Sarah Lieder, P. I. Nikel, V. de Lorenzo, R. Takors
- Biology, Medicine
- Microbial Cell Factories
- 21 February 2015
BackgroundThe implementation of novel platform organisms to be used as microbial cell factories in industrial applications is currently the subject of intense research. Ongoing efforts include the… Expand