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Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry.
- Bing Luo, Karsten Groenke, R. Takors, C. Wandrey, M. Oldiges
- Chemistry, BiologyJournal of Chromatography A
- 20 April 2007
Metabolomics: quantification of intracellular metabolite dynamics.
- A. Buchholz, J. Hurlebaus, C. Wandrey, R. Takors
- BiologyBiomolecular Engineering
- 1 June 2002
Scale-up of microbial processes: impacts, tools and open questions.
- R. Takors
- Biology, EngineeringJournal of Biotechnology
- 31 July 2012
Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments.
- K. Nöh, K. Grönke, Bing Luo, R. Takors, M. Oldiges, W. Wiechert
- BiologyJournal of Biotechnology
- 30 April 2007
Platform Engineering of Corynebacterium glutamicum with Reduced Pyruvate Dehydrogenase Complex Activity for Improved Production of l-Lysine, l-Valine, and 2-Ketoisovalerate
- Jens Buchholz, A. Schwentner, B. Blombach
- Biology, EngineeringApplied and Environmental Microbiology
- 8 July 2013
ABSTRACT Exchange of the native Corynebacterium glutamicum promoter of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex (PDHC), with mutated dapA promoter variants led to…
High Substrate Uptake Rates Empower Vibrio natriegens as Production Host for Industrial Biotechnology
- E. Hoffart, S. Grenz, B. Blombach
- Biology, EngineeringApplied and Environmental Microbiology
- 8 September 2017
The fastest-growing nonpathogenic bacterium, Vibrio natriegens, is identified as a novel candidate for future biotechnological processes and a promising new microbial platform for future industrial fermentation processes operating with high productivity.
Sensitivity analysis for the reduction of complex metabolism models
- D. Degenring, C. Froemel, G. Dikta, R. Takors
- Engineering
- 1 October 2004
Stimulation, Monitoring, and Analysis of Pathway Dynamics by Metabolic Profiling in the Aromatic Amino Acid Pathway
- M. Oldiges, M. Kunze, D. Degenring, G. Sprenger, R. Takors
- BiologyBiotechnology progress
- 2004
The results underline the necessity to extend the focus of glucose pulse experiments by studying not only the central metabolism but also anabolic pathways and identify promising metabolic engineering targets to alleviate respective flux control in subsequent l‐Phe producing strains.
Process strategies to enhance pyruvate production with recombinant Escherichia coli: From repetitive fed‐batch to in situ product recovery with fully integrated electrodialysis
- B. Zelić, Srđan Gostović, K. Vuorilehto, Đ. Vasić-Rački, R. Takors
- Biology, EngineeringBiotechnology and Bioengineering
- 20 March 2004
Using the pyruvate production strain Escherichia coli YYC202 ldhA::Kan different process alternatives are studied with the aim of preventing potential product inhibition by appropriate product…
Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains.
- M. Gerigk, R. Bujnicki, E. Ganpo-Nkwenkwa, J. Bongaerts, G. Sprenger, R. Takors
- Engineering, BiologyBiotechnology and Bioengineering
- 30 December 2002
A novel fed-batch approach for the production of L-phenylalanine (L-Phe) with recombinant E. coli is presented concerning the on-line control of the key fermentation parameters glucose and tyrosine.…
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