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A Theoretical Model for Utilizing Mammalian Pharmacology and Safety Data to Prioritize Potential Impacts of Human Pharmaceuticals to Fish
A model has been developed to utilize the information from mammalian pharmacology and toxicology studies to evaluate the potential for chronic receptor mediated responses in fish and to strengthen the applicability of this approach as a viable tool for prioritizing research initiatives that examine the potential impact of pharmaceuticals on fish.
Corn Oil in Treatment of Ischaemic Heart Disease
(3) Absence of heart failure, and also of any non-cardiac disease likely to threaten life within two years. (4) Absence of personal or geographical factors likely to interfere with clinic attendance…
The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat.
- R. Gingell, J. Bridges, R. T. Williams
- Biology, MedicineXenobiotica; the fate of foreign compounds in…
- 1 March 1971
1. The urinary excretion of total sulphanilamide (free and acetylated) in rats receiving Prontosil or Neoprontosil orally is considerably reduced when the rats are treated with antibiotics to…
Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine.
- I. Kitchen, J. Tremblay, R. T. Williams
- Chemistry, BiologyXenobiotica; the fate of foreign compounds in…
- 1 July 1979
Inter-individual differences in oxidative O-demethylation of the drug are discussed in relation to current theories on the aetiology of schizophrenia and reported fatalities arising from abuse of theDrug.
The fate of benzoic acid in various species.
It appears that the hedgehog and ferret are like the dog in respect to their metabolism of benzoic acid, and the Indian fruit bat produced only traces of hippuric acid and possibly has a defect in the glycine conjugation of benzosic acid.
Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria.
The results support the view that quinic acid and shikimic acid are aromatized by the gut flora in man and the Old World monkeys.
Metabolism of [14C]methamphetamine in man, the guinea pig and the rat
The main reaction in the rat was aromatic hydroxylation, in the guinea pig demethylation and deamination, whereas in man much of the drug, possibly one-half, was excreted unchanged, and Marked species differences in the metabolism of methamphetamine were observed.
Detoxication mechanisms : the metabolism and detoxication of drugs, toxic substances and other organic compounds
- R. T. Williams
The metabolism of 2:4:6-trinitrotoluene (α-T.N.T.)
Separation of acetyl-phenylanine and acetyl-leucine For the trial separations synthetic mixtures of acetylphenylalanine (1-84 mg.) and acetyl-leucine (2.06 mg.) were used. Columns were made up, as…