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Alterations in the functional properties of skinned fibers from denervated rabbit skeletal muscle.
Isometric tension was recorded in vitro from chemically skinned fibers obtained from normal and 14-day-denervated extensor digitorum longus muscles of the rabbit. Denervation potentiated the tensionsExpand
Dantrolene Sodium Can Increase or Attenuate Activity of Skeletal Muscle Ryanodine Receptor Calcium Release Channel: Clinical Implications
Background Dantrolene sodium (DS) is a direct‐acting skeletal muscle relaxant whose only known action is to block calcium release from intracellular storage sites. The exact site of action for DS isExpand
1 Brazilian forests show high diversity of medicinal plants and several are used in folk medicine for the treatment of hypertension and asthma. The aim of the present study was to investigate theExpand
Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta
The essential oil of Pectis brevipedunculata (EOPB), a Brazilian ornamental aromatic grass, is characterized by its high content of citral (81.9%: neral 32.7% and geranial 49.2%), limonene (4.7%) andExpand
Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a clinical condition characterized by pulmonary arterial remodeling and vasoconstriction, which promote chronic vessel obstruction and elevation of pulmonaryExpand
Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives.
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed byExpand
Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats.
The renal renin-angiotensin system plays a central role in the development of hypertension. The aim of this work was to verify the expression of angiotensin II receptors AT(1)R and AT(2)R in theExpand
Sedative and anticonvulsant activities of methanol extract of Dorstenia arifolia in mice.
ETHNOPHARMACOLOGICAL RELEVANCE Dorstenia arifolia is a plant that has been used in the folk medicine to produce hypnotic, sedative and ansiolitic effects but the pharmacological properties have notExpand
Activation of GPER ameliorates experimental pulmonary hypertension in male rats
Rationale: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right‐ventricle (RV) failure, and premature death.Expand
Calcium-Sensitizing Function for the Dipeptide Carnosine in Skeletal Muscle Contractility
Carnosine (α-alanyl- l -histidine), a dipeptide, the exact functions of which are unknown, is found at millimolar concentrations in muscle cells. In skinned skeletal muscle fibers, ca