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Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats
TLDR
DPG3 was significantly less able to causeperiodontal bone loss in a gnotobiotic rat model of periodontal disease and these observations are consistent with other data suggesting that P. gingivalis fimbriae play an important role in the pathogenesis of human periodontAL disease.
An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals.
TLDR
Results indicate a nonredundant role for IL-17 in mediating host defense via neutrophil mobilization in periodontal disease and in inflammatory bone loss induced by the oral pathogen Porphyromonas gingivalis in IL- 17RA-deficient mice.
CD4+ T Cells and the Proinflammatory Cytokines Gamma Interferon and Interleukin-6 Contribute to Alveolar Bone Loss in Mice
TLDR
The results suggest that the adaptive immune response, and in particular CD4+ T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection.
Transfer of Bacteroides splanchnicus to Odoribacter gen. nov. as Odoribacter splanchnicus comb. nov., and description of Odoribacter denticanis sp. nov., isolated from the crevicular spaces of canine
TLDR
Based on biochemical, morphological, molecular phylogenetic, and pathogenic evidence, it is proposed that the taxonomic subgroup containing these novel isolates and B. splanchnicus should be classified in a new genus, Odoribacter gen. nov, within the family 'Porphyromonadaceae'.
Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice.
TLDR
It is shown that in mice with a background oral microflora bone loss is induced by a specific infection with P. gingivalis and that bacterial strain variation is important in determining whether alveolar bone loss will ensue.
Tannerella forsythia-induced Alveolar Bone Loss in Mice Involves Leucine-rich-repeat BspA Protein
TLDR
Evidence is presented in support of T. forsythia as an important organism involved in inducing alveolar bone loss, and the BspA protein is an important virulence factor of this bacterium.
Two complementary methods of assessing periodontal bone level in rats.
TLDR
It is concluded that future studies would benefit from applying both methods to assess alveolar bone loss in rats, since the morphometric method mainly measures horizontal bone loss, whereas the radiographic method detects intrabony interproximal defects.
A Non‐Antimicrobial Tetracycline Inhibits Gingival Matrix Metalloproteinases and Bone Loss in Porphyromonas gingivalis‐induced Periodontitis in Rats a
TLDR
The tetracycline antibiotics, which have long been used as adjuncts in periodontal therapy based on their antimicrobial effectiveness against a variety of suspected periodontopathic microorganisms, are now known to also inhibit pathologically excessive host-derived MMP activity during periodontals and other diseases, although the mechanisms of action are not yet well defined.
Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism.
TLDR
Serum antibody levels were significantly elevated in the 3 infected groups compared to the non-infected controls, indicated that these groups of rats were infected with P. gingivalis.
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