• Publications
  • Influence
Subchronic toxicity studies of N-D-ornithyl amphotericin B methyl ester in dogs and rats.
Two subchronic studies were conducted to assess the potential toxicity of N-D-ornithyl amphotericin B methyl ester (OAME). In both studies the comparative control substance was amphotericin B (AMB).Expand
  • 11
  • 2
Influence of Origin or Controlled Feeding On Longevity of Sprague-Dawley Rats
Two-year studies were undertaken in Sprague-Dawley (SD) rats to assess the effects of origin, group housing, or various feeding regimens on longevity. This report describes results of in-lifeExpand
  • 6
  • 2
Preclinical Toxicology Studies with Acyclovir: Acute and Subchronic Tests
Acyclovir (ACV), a new antiherpes drug, was evaluated for toxicity in a series of acute and subchronic toxicity tests. Oral LD50 values were greater than 10 000 mg/kg in male ICR mice and greaterExpand
  • 32
  • 1
Comparative toxicity of netilmicin and tobramycin in dogs.
Abstract Beagle dogs (four/group) were dosed intramuscularly with netilmicin or tobramycin once daily at doses of 20, 40, or 80 mg/kg. The dogs were dosed for 30 days or until death or sacrificeExpand
  • 16
Eighteen month oral study of aspirin, phenacetin and caffeine, in C57Bl/6 mice.
Groups of 40 male and 40 female C57BL/6 mice were maintained for 75-80 weeks on meal form diets containing aspirin, phenacetin and caffeine either singly or in combination. The maximum daily doses ofExpand
  • 36
Preclinical toxicology studies with acyclovir: acute and subchronic tests.
Acyclovir (ACV), a new antiherpes drug, was evaluated for toxicity in a series of acute and subchronic toxicity tests. Oral LD50 values were greater than 10 000 mg/kg in male ICR mice and greaterExpand
  • 27
Preclinical Toxicity Evaluation of Tepoxalin, a Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase, in Sprague–Dawley Rats and Beagle Dogs☆
Abstract Tepoxalin [5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide] is an orally active anti-inflammatory agent, which inhibits both cyclooxygenase andExpand
  • 22
Preclinical toxicity evaluation of tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, in Sprague-Dawley rats and beagle dogs.
Tepoxalin [5- (4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole -3-propanamide] is an orally active anti-inflammatory agent, which inhibits both cyclooxygenase and 5-lipoxygenaseExpand
  • 26
Preclinical toxicology studies with acyclovir: ophthalmic and cutaneous tests.
Topical formulations of acyclovir (ACV) were tested in animals to define potential for tissue irritation and systemic toxicity. Acyclovir ointments (5 and 10% concentrations in polyethylene glycolExpand
  • 4
Preclinical toxicology studies with acyclovir: ophthalmic and cutaneous tests.
Abstract Topical formulations of acyclovir (ACV) were tested in animals to define potential for tissue irritation and systemic toxicity. Acyclovir ointments (5 and 10% concentrations in polyethyleneExpand
  • 8