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- Publications
- Influence
Subchronic toxicity studies of N-D-ornithyl amphotericin B methyl ester in dogs and rats.
- T. Massa, D. Sinha, +7 authors H. E. Black
- Medicine
- Fundamental and applied toxicology : official…
- 1985
Two subchronic studies were conducted to assess the potential toxicity of N-D-ornithyl amphotericin B methyl ester (OAME). In both studies the comparative control substance was amphotericin B (AMB).… Expand
Influence of Origin or Controlled Feeding On Longevity of Sprague-Dawley Rats
- E. Knight, D. S. Barrett, +6 authors W. Powers
- Medicine
- 1 February 1998
Two-year studies were undertaken in Sprague-Dawley (SD) rats to assess the effects of origin, group housing, or various feeding regimens on longevity. This report describes results of in-life… Expand
Preclinical Toxicology Studies with Acyclovir: Acute and Subchronic Tests
- W. Tucker, Alexander W. Macklin, +4 authors G. Szczech
- Medicine
- 1 November 1983
Acyclovir (ACV), a new antiherpes drug, was evaluated for toxicity in a series of acute and subchronic toxicity tests. Oral LD50 values were greater than 10 000 mg/kg in male ICR mice and greater… Expand
Comparative toxicity of netilmicin and tobramycin in dogs.
- R. Szot, G. Mccormick, M. Chung, B. Christie, E. Weinberg, E. Schwartz
- Medicine
- Toxicology and applied pharmacology
- 1 August 1980
Abstract Beagle dogs (four/group) were dosed intramuscularly with netilmicin or tobramycin once daily at doses of 20, 40, or 80 mg/kg. The dogs were dosed for 30 days or until death or sacrifice… Expand
Eighteen month oral study of aspirin, phenacetin and caffeine, in C57Bl/6 mice.
- A. Macklin, R. Szot
- Chemistry, Medicine
- Drug and chemical toxicology
- 1980
Groups of 40 male and 40 female C57BL/6 mice were maintained for 75-80 weeks on meal form diets containing aspirin, phenacetin and caffeine either singly or in combination. The maximum daily doses of… Expand
Preclinical toxicology studies with acyclovir: acute and subchronic tests.
- W. Tucker, A. Macklin, +4 authors G. Szczech
- Medicine
- Fundamental and applied toxicology : official…
- 1983
Acyclovir (ACV), a new antiherpes drug, was evaluated for toxicity in a series of acute and subchronic toxicity tests. Oral LD50 values were greater than 10 000 mg/kg in male ICR mice and greater… Expand
Preclinical Toxicity Evaluation of Tepoxalin, a Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase, in Sprague–Dawley Rats and Beagle Dogs☆
- E. V. Knight, J. P. Kimball, +8 authors R. Szot
- Chemistry
- 1 September 1996
Abstract Tepoxalin [5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide] is an orally active anti-inflammatory agent, which inhibits both cyclooxygenase and… Expand
Preclinical toxicity evaluation of tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, in Sprague-Dawley rats and beagle dogs.
- E. V. Knight, J. Kimball, +8 authors R. Szot
- Medicine
- Fundamental and applied toxicology : official…
- 1996
Tepoxalin [5- (4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole -3-propanamide] is an orally active anti-inflammatory agent, which inhibits both cyclooxygenase and 5-lipoxygenase… Expand
Preclinical toxicology studies with acyclovir: ophthalmic and cutaneous tests.
- W. Tucker, R. E. Johnston, +4 authors G. Szczech
- Medicine
- Fundamental and applied toxicology : official…
- 1983
Topical formulations of acyclovir (ACV) were tested in animals to define potential for tissue irritation and systemic toxicity. Acyclovir ointments (5 and 10% concentrations in polyethylene glycol… Expand
Preclinical toxicology studies with acyclovir: ophthalmic and cutaneous tests.
- W. Tucker, R. E. Johnston, +4 authors G. Szczech
- Medicine
- 1 November 1983
Abstract Topical formulations of acyclovir (ACV) were tested in animals to define potential for tissue irritation and systemic toxicity. Acyclovir ointments (5 and 10% concentrations in polyethylene… Expand