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Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic transcription factors that mediate intracellular signaling that is usually generated at cell surfaceExpand
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Secreted frizzled related proteins: Implications in cancers.
The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, andExpand
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Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths inExpand
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Targeted Inhibition of Multiple Proinflammatory Signalling Pathways for the Prevention and Treatment of Multiple Myeloma
Radhamani Kannaiyan1, Rohit Surana1,2, Eun Myoung Shin2, Lalitha Ramachandran1, Gautam Sethi1,2,* and Alan Prem Kumar1,2,3,* 1Department of Pharmacology, Yong Loo Lin School of Medicine, NationalExpand
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Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer*
Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential forExpand
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Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of Multiple Myeloma
Multiple myeloma (MM) is a malignant plasma cell tumor often arising in the bone marrow and is the most common non-Hodgkin’s haematological malignancy contributing 13 % of all malignancy and 1 % ofExpand
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Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
The authors recently recognized an error in Fig. 6C, where the vehicle control image was erroneously found to be duplicated from control image in Fig. 4A of another article published by their groupExpand