• Publications
  • Influence
KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
TLDR
A novel association between CaM kinase activation and EADs is shown and this is consistent with the hypothesis that the ICa and CaM Kinase activation both contribute to Eads in this model. Expand
Electrophysiologic Mechanisms of the Long QT Interval Syndromes and Torsade de Pointes
TLDR
The acquired and hereditary long QT interval syndromes and the form of polymorphic ventricular tachycardia associated with them have now become a model of the ways in which identifiable cellular electrophysiologic abnormalities can cause clinical cardiac arrhythmia. Expand
Spatial Heterogeneity of Calcium Transient Alternans During the Early Phase of Myocardial Ischemia in the Blood-Perfused Rabbit Heart
TLDR
These results demonstrate marked spatial heterogeneity of the [Ca2+]i transient during the early phase of ischemia, which could produce electrical instability and arrhythmias in large mammalian hearts. Expand
Clinical, electrophysiologic and hemodynamic profile of patients resuscitated from prehospital cardiac arrest.
TLDR
The electrical mechanism of prehospital cardiac arrest provides early prognostic information, that early survival rates are improving and that one third of the discharged survivors have normal indices of left ventricular function. Expand
Myocardial ischemia and ventricular fibrillation: pathophysiology and clinical implications.
TLDR
Reentry models described are spiral wave reentry, 3 dimensional rotors, reentry around 'M' cells and figure-of-eight re entry, which transforms triggers into VF and serves to maintain it through fragmentation of waves in the ischemic zone. Expand
Long-term electrophysiological abnormalities resulting from experimental myocardial infarction in cats.
TLDR
The role of 12 angiotensin in the canine renal vascular response to barbiturate anesthesia and its effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat are studied. Expand
Verapamil for Control of Ventricular Rate in Paroxysmal Supraventricular Tachycardia and Atrial Fibrillation or Flutter: A Double-Blind Randomized Cross-Over Study
TLDR
It is concluded that verapamil results in a clinically significant slowing of the ventricular response in atrial fibrillation or atrial flutter and is superior to placebo for conversion of paroxysmal supraventricular tachycardia to sinus rhythm. Expand
Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation.
TLDR
Although large-dose amiodarone is highly effective in the long-term treatment of VT or VF refractory to conventional antiarrhythmic drugs, it causes significant toxicity in approximately 50% of patients, however, when the dose is adjusted based on clinical response or the development of adverse effects, 75%. Expand
Initiation of two distinct forms of atrioventricular nodal reentrant tachycardia during programmed ventricular stimulation in man.
TLDR
In both groups of patients, the ventricular pacing cycle length appeared to be a crucial factor in the ability to expose functional discordance between the two A-V nodal pathways during retrograde conduction. Expand
Erythromycin ototoxicity: prospective assessment with serum concentrations and audiograms in a study of patients with pneumonia.
TLDR
Patients receiving erythromycin, especially at a total daily dose of 4 g, should be monitored regularly for subjective evidence of sensorineural hearing dysfunction, as well as dose- and serum concentration-dependent ototoxicity. Expand
...
1
2
3
4
5
...