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The role of lipid rafts in LPS-induced signaling in a macrophage cell line.
The significance of lipid rafts in lipopolysaccharide (LPS) signaling in macrophages was studied through isolation of them by gradient centrifugation and subsequent visualization of signal molecules… Expand
Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates.
The effects of choline, ethanolamine and its N-methyl analogs, different fatty acids, and L-methionine on phospholipid biosynthesis via the CDP-ester pathways and the methylation pathway were studied… Expand
Bafilomycin A1 inhibits lysosomal, phagosomal, and plasma membrane H+‐ATPase and induces lysosomal enzyme secretion in macrophages
Bafilomycin A1, a specific inhibitor of H+‐ATPases of the vacuolar type, was in the present study shown, at similar concentrations, to induce secretion of lysosomal enzyme and to elevate lysosomal pH… Expand
Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver.
- R. Sundler
- Medicine, Chemistry
- The Journal of biological chemistry
- 25 November 1975
Ethanolaminephosphate cytidylyltransferase (EC 18.104.22.168), which catalyzes a central step in phosphatidylethanolamine synthesis, has been purified 1000-fold from a postmicrosomal supernatant from rat… Expand
Dexamethasone down-regulates the 85 kDa phospholipase A2 in mouse macrophages and suppresses its activation.
We have studied the effects of dexamethasone (dex) (i) on the level of the arachidonate-mobilizing phospholipase A2 (PLA2-85) in macrophages, (ii) on the stimulus-induced activation of this enzyme,… Expand
Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages.
Resident mouse macrophages secrete Tumor necrosis factor alpha (TNFalpha) upon challenge with LPS. The production of TNFalpha is controlled not only at the transcription of the gene, but also by… Expand
An 100-kDa arachidonate-mobilizing phospholipase A2 in mouse spleen and the macrophage cell line J774. Purification, substrate interaction and phosphorylation by protein kinase C.
A phospholipase A2 hydrolyzing arachidonic-acid-containing phospholipids has been purified 5600-fold from mouse spleen and to near homogeneity from the macrophage cell line J774. A molecular mass of… Expand
Control of membrane fusion by phospholipid head groups. II. The role of phosphatidylethanolamine in mixtures with phosphatidate and phosphatidylinositol.
- R. Sundler, N. Düzgüneş, D. Papahadjopoulos
- Chemistry, Medicine
- Biochimica et biophysica acta
- 21 December 1981
Membrane fusion induced by Ca2+ and Mg2+ in large unilamellar vesicles composed of mixtures of phosphatidylethanolamine with phosphatidate and phosphatidylinositol was studied by means of a… Expand
Signaling to localized degranulation in neutrophils adherent to immune complexes
- C. Nauclér, S. Grinstein, R. Sundler, H. Tapper
- Biology, Medicine
- Journal of leukocyte biology
- 1 April 2002
The present study demonstrates that the secretion of azurophilic granules occurring during Fc receptor‐mediated attachment and spreading of neutrophils is highly localized to the adhering region of… Expand
Signalling to translational activation of tumour necrosis factor-alpha expression in human THP-1 cells.
Monocytic THP-1 cells expressed tumour necrosis factor-alpha (TNF-alpha) mRNA, but hardly any detectable TNF-alpha protein and a partially activated MAP kinase ERK-2 in the unstimulated state.… Expand