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Ethanolic Extract of Papaya (Carica papaya) Leaf Exhibits Estrogenic Effects In Vivo and In Silico
The menopause women have the low level of estrogen in the body. The lack of estrogen changes physiological function in women’s body that affects in health condition. Carica papaya L. leaf containsExpand
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NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis
NOTCH receptor signaling plays a pivotal role in liver homeostasis and hepatocarcinogenesis. However, the role of NOTCH pathway mutations and the NOTCH target gene HES5 in liver tumorigenesis areExpand
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Caesalpinia sappan L. heartwood ethanolic extract exerts genotoxic inhibitory and cytotoxic effects
Brazilin and brazilein, the major compounds of Caesalpinia sappan L. (CS) have been reported to possess antioxidant and cytotoxic activities and could potentially be used as an antigenotoxic as wellExpand
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APLIKASI KAYU SECANG (Caesalpinia sappan L.) DALAM UPAYA PREVENSI KERUSAKAN DNA AKIBAT PAPARAN ZAT POTENSIAL KARSINOGENIK MELALUI MNPCE ASSAY
Genotoxic effect is related to the mutation of the gene in the DNA. Caesalpinia sappan L. is one of Caesalpiniaceae family found in Indonesia containing brazilin and brazilein. It has been reportedExpand
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Ethanolic Extract of Papaya (Carica papaya) Leaves Improves Blood Cholesterol Profiles and Bone Density in Ovariectomized Rats
Bone loss and disturbance in the blood cholesterol profiles modulation are two effects caused by menopauses syndromes. As the estrogen concentration in the body decreased drastically, menopause womenExpand
IMAHO (INDONESIA MALAYSIA IN HARMONY): STRATEGI CERDAS ALA MAHASISWA KESEHATAN DALAM MEMBANGUN KERUKUNAN RUMPUN MALAYA
Indonesia and Malaysia relationship as two neighbouring countries often face bilateral problems, for example cultural, political, and social conflicts. Some solutions for those conflicts had alreadyExpand
Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria
Chromosome 8p is frequently deleted in various cancer entities and has been shown to correlate with poor patient survival. SH2D4A is located on chromosome 8p and prevents the nuclear translocation ofExpand
Cytotoxic and Apoptotic-inducing Effect of Fraction Containing Brazilein from Caesalpinia sappan L. and Cisplatin on T47D Cell Lines
Anticancer activity of secang’s heartwood ( Caesalpinia sappan L.) is based on its main compound: brazilin and brazilein. Brazilin, brazilein, and other compounds such as caesalpiniaphenol can affectExpand